FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048177597> ?p ?o ?g. }

• W2048177597 endingPage "607" @default.
• W2048177597 startingPage "598" @default.
• W2048177597 abstract "Dipeptidyl peptidase IV (DPPIV) is an exopeptidase that modulates the function of several substrates, among which insulin-releasing incretin hormones are the most well known. DPPIV also modulate substrates involved in inflammation, cell migration, and cell differentiation. Although DPPIV is highly expressed in proximal renal tubular cells, the role of DPPIV inhibition in renal disease is not fully understood. For this reason, we investigated the effects of LC15-0444, a DPPIV inhibitor, on renal function in a mouse model of renal fibrosis. Eight-week-old C57/BL6 mice were subjected to unilateral ureteral obstruction (UUO) and were treated with LC15-0444 (a DPPIV inhibitor) at a dose of 150 mg/kg per day in food or vehicle for 14 days. DPPIV activity was significantly increased in obstructed kidneys, and reduced after treatment with LC15-0444. Administration of LC15-0444 resulted in a significant decrease in albuminuria, urinary excretion of 8-isoprostane, and renal fibrosis. DPPIV inhibition also substantially decreased the synthesis of several proinflammatory and profibrotic molecules, as well as the infiltration of macrophages. UUO significantly increased, and LC15-0444 markedly suppressed, levels of phosphorylated Smad2/3, TGFβ1, toll-like receptor 4, high-mobility group box-1, NADPH oxidase 4, and NF-κB. These results suggest that activation of DPPIV in the kidney has a role in the progression of renal disease and that targeted therapy inhibiting DPPIV may prove to be a useful new approach in the management of progressive renal disease, independent of mechanisms mediated by glucagon-like peptide-1." @default.
• W2048177597 created "2016-06-24" @default.
• W2048177597 creator A5002056660 @default.
• W2048177597 creator A5003518823 @default.
• W2048177597 creator A5018869195 @default.
• W2048177597 creator A5021371016 @default.
• W2048177597 creator A5029273230 @default.
• W2048177597 creator A5038989519 @default.
• W2048177597 creator A5052186852 @default.
• W2048177597 creator A5056406805 @default.
• W2048177597 creator A5062995192 @default.
• W2048177597 creator A5068577882 @default.
• W2048177597 creator A5069855644 @default.
• W2048177597 creator A5080886354 @default.
• W2048177597 creator A5086842226 @default.
• W2048177597 date "2014-06-01" @default.
• W2048177597 modified "2023-10-10" @default.
• W2048177597 title "Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction" @default.
• W2048177597 cites W1539698363 @default.
• W2048177597 cites W1573917252 @default.
• W2048177597 cites W1584353300 @default.
• W2048177597 cites W1973037639 @default.
• W2048177597 cites W1984363640 @default.
• W2048177597 cites W1985187709 @default.
• W2048177597 cites W1988976004 @default.
• W2048177597 cites W1996710793 @default.
• W2048177597 cites W2006211642 @default.
• W2048177597 cites W2008286952 @default.
• W2048177597 cites W2009530082 @default.
• W2048177597 cites W2011415835 @default.
• W2048177597 cites W2017351479 @default.
• W2048177597 cites W2018576497 @default.
• W2048177597 cites W2018653121 @default.
• W2048177597 cites W2020492939 @default.
• W2048177597 cites W2031468509 @default.
• W2048177597 cites W2055665437 @default.
• W2048177597 cites W2067006074 @default.
• W2048177597 cites W2078560791 @default.
• W2048177597 cites W2082768293 @default.
• W2048177597 cites W2083473802 @default.
• W2048177597 cites W2096816598 @default.
• W2048177597 cites W2100495055 @default.
• W2048177597 cites W2111123038 @default.
• W2048177597 cites W2113985146 @default.
• W2048177597 cites W2124175932 @default.
• W2048177597 cites W2140655321 @default.
• W2048177597 cites W2150859826 @default.
• W2048177597 cites W2159110261 @default.
• W2048177597 cites W2159205789 @default.
• W2048177597 cites W2161954266 @default.
• W2048177597 cites W2163986399 @default.
• W2048177597 cites W2164875000 @default.
• W2048177597 cites W2166051277 @default.
• W2048177597 cites W2170003639 @default.
• W2048177597 cites W2401589271 @default.
• W2048177597 cites W2412434277 @default.
• W2048177597 cites W4240629327 @default.
• W2048177597 doi "https://doi.org/10.1038/labinvest.2014.50" @default.
• W2048177597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24687121" @default.
• W2048177597 hasPublicationYear "2014" @default.
• W2048177597 type Work @default.
• W2048177597 sameAs 2048177597 @default.
• W2048177597 citedByCount "59" @default.
• W2048177597 countsByYear W20481775972014 @default.
• W2048177597 countsByYear W20481775972015 @default.
• W2048177597 countsByYear W20481775972016 @default.
• W2048177597 countsByYear W20481775972017 @default.
• W2048177597 countsByYear W20481775972018 @default.
• W2048177597 countsByYear W20481775972019 @default.
• W2048177597 countsByYear W20481775972020 @default.
• W2048177597 countsByYear W20481775972021 @default.
• W2048177597 countsByYear W20481775972022 @default.
• W2048177597 countsByYear W20481775972023 @default.
• W2048177597 crossrefType "journal-article" @default.
• W2048177597 hasAuthorship W2048177597A5002056660 @default.
• W2048177597 hasAuthorship W2048177597A5003518823 @default.
• W2048177597 hasAuthorship W2048177597A5018869195 @default.
• W2048177597 hasAuthorship W2048177597A5021371016 @default.
• W2048177597 hasAuthorship W2048177597A5029273230 @default.
• W2048177597 hasAuthorship W2048177597A5038989519 @default.
• W2048177597 hasAuthorship W2048177597A5052186852 @default.
• W2048177597 hasAuthorship W2048177597A5056406805 @default.
• W2048177597 hasAuthorship W2048177597A5062995192 @default.
• W2048177597 hasAuthorship W2048177597A5068577882 @default.
• W2048177597 hasAuthorship W2048177597A5069855644 @default.
• W2048177597 hasAuthorship W2048177597A5080886354 @default.
• W2048177597 hasAuthorship W2048177597A5086842226 @default.
• W2048177597 hasBestOaLocation W20481775971 @default.
• W2048177597 hasConcept C126322002 @default.
• W2048177597 hasConcept C134018914 @default.
• W2048177597 hasConcept C156490143 @default.
• W2048177597 hasConcept C159641895 @default.
• W2048177597 hasConcept C164027704 @default.
• W2048177597 hasConcept C181199279 @default.
• W2048177597 hasConcept C185592680 @default.
• W2048177597 hasConcept C2776174234 @default.
• W2048177597 hasConcept C2776398474 @default.
• W2048177597 hasConcept C2776914184 @default.

• next