FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048202372> ?p ?o ?g. }

• W2048202372 endingPage "735" @default.
• W2048202372 startingPage "731" @default.
• W2048202372 abstract "Oligodendrocytes develop from a subpopulation of precursor cells within the ventral ventricular zone of the spinal cord. The molecular cues that direct this spatially and temporally restricted event seem to originate in part from structures ventral to and within the spinal cord. Here, we present evidence that the family of ligands termed neuregulins are necessary for the normal generation of mouse spinal cord oligodendrocytes. Oligodendrocytes mature in spinal cord explants from wild-type mice and mice heterozygotic for a null mutation in the neuregulin gene (NRG +/−) in a temporal sequence of developmental events that replicates that observed in vivo . However, in spinal cord explants derived from mice lacking neuregulin (NRG −/−), oligodendrocytes fail to develop. Addition of recombinant neuregulin to spinal cord explants from NRG −/− mice rescues oligodendrocyte development. In wild-type spinal cord explants, inhibitors of neuregulin mimic the inhibition of oligodendrocyte development that occurs in NRG −/− explants. In embryonic mouse spinal cord, neuregulins are present in motor neurons and the ventral ventricular zone where they likely exert their influence on early oligodendrocyte precursor cells." @default.
• W2048202372 created "2016-06-24" @default.
• W2048202372 creator A5030332501 @default.
• W2048202372 creator A5039163206 @default.
• W2048202372 creator A5068705235 @default.
• W2048202372 date "1999-01-19" @default.
• W2048202372 modified "2023-09-27" @default.
• W2048202372 title "Failure of spinal cord oligodendrocyte development in mice lacking neuregulin" @default.
• W2048202372 cites W1488828742 @default.
• W2048202372 cites W1560013316 @default.
• W2048202372 cites W1971414704 @default.
• W2048202372 cites W1973188134 @default.
• W2048202372 cites W1977333251 @default.
• W2048202372 cites W1978338248 @default.
• W2048202372 cites W1979844086 @default.
• W2048202372 cites W1980141913 @default.
• W2048202372 cites W1981108516 @default.
• W2048202372 cites W1982180728 @default.
• W2048202372 cites W1982210988 @default.
• W2048202372 cites W1987657791 @default.
• W2048202372 cites W1990654868 @default.
• W2048202372 cites W1997914540 @default.
• W2048202372 cites W1998931558 @default.
• W2048202372 cites W2004813091 @default.
• W2048202372 cites W2013331112 @default.
• W2048202372 cites W2016010426 @default.
• W2048202372 cites W2032972759 @default.
• W2048202372 cites W2036550297 @default.
• W2048202372 cites W2048905477 @default.
• W2048202372 cites W2060413384 @default.
• W2048202372 cites W2064168648 @default.
• W2048202372 cites W2076682664 @default.
• W2048202372 cites W2077492083 @default.
• W2048202372 cites W2077665580 @default.
• W2048202372 cites W2081560586 @default.
• W2048202372 cites W2094895636 @default.
• W2048202372 cites W2107427447 @default.
• W2048202372 cites W2115940913 @default.
• W2048202372 cites W2116585991 @default.
• W2048202372 cites W2122788299 @default.
• W2048202372 cites W2127208829 @default.
• W2048202372 cites W2139709351 @default.
• W2048202372 cites W2147334994 @default.
• W2048202372 cites W2151127067 @default.
• W2048202372 cites W2159363679 @default.
• W2048202372 cites W2343053880 @default.
• W2048202372 doi "https://doi.org/10.1073/pnas.96.2.731" @default.
• W2048202372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/15205" @default.
• W2048202372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9892702" @default.
• W2048202372 hasPublicationYear "1999" @default.
• W2048202372 type Work @default.
• W2048202372 sameAs 2048202372 @default.
• W2048202372 citedByCount "156" @default.
• W2048202372 countsByYear W20482023722012 @default.
• W2048202372 countsByYear W20482023722013 @default.
• W2048202372 countsByYear W20482023722014 @default.
• W2048202372 countsByYear W20482023722015 @default.
• W2048202372 countsByYear W20482023722016 @default.
• W2048202372 countsByYear W20482023722017 @default.
• W2048202372 countsByYear W20482023722018 @default.
• W2048202372 countsByYear W20482023722019 @default.
• W2048202372 countsByYear W20482023722020 @default.
• W2048202372 countsByYear W20482023722021 @default.
• W2048202372 countsByYear W20482023722022 @default.
• W2048202372 countsByYear W20482023722023 @default.
• W2048202372 crossrefType "journal-article" @default.
• W2048202372 hasAuthorship W2048202372A5030332501 @default.
• W2048202372 hasAuthorship W2048202372A5039163206 @default.
• W2048202372 hasAuthorship W2048202372A5068705235 @default.
• W2048202372 hasBestOaLocation W20482023721 @default.
• W2048202372 hasConcept C105702510 @default.
• W2048202372 hasConcept C126838900 @default.
• W2048202372 hasConcept C141071460 @default.
• W2048202372 hasConcept C143409427 @default.
• W2048202372 hasConcept C169760540 @default.
• W2048202372 hasConcept C185323287 @default.
• W2048202372 hasConcept C2776985911 @default.
• W2048202372 hasConcept C2778560701 @default.
• W2048202372 hasConcept C2778609137 @default.
• W2048202372 hasConcept C2779055221 @default.
• W2048202372 hasConcept C2779632786 @default.
• W2048202372 hasConcept C2780775167 @default.
• W2048202372 hasConcept C2781192897 @default.
• W2048202372 hasConcept C529278444 @default.
• W2048202372 hasConcept C62478195 @default.
• W2048202372 hasConcept C71924100 @default.
• W2048202372 hasConcept C86803240 @default.
• W2048202372 hasConcept C95444343 @default.
• W2048202372 hasConceptScore W2048202372C105702510 @default.
• W2048202372 hasConceptScore W2048202372C126838900 @default.
• W2048202372 hasConceptScore W2048202372C141071460 @default.
• W2048202372 hasConceptScore W2048202372C143409427 @default.
• W2048202372 hasConceptScore W2048202372C169760540 @default.
• W2048202372 hasConceptScore W2048202372C185323287 @default.
• W2048202372 hasConceptScore W2048202372C2776985911 @default.
• W2048202372 hasConceptScore W2048202372C2778560701 @default.
• W2048202372 hasConceptScore W2048202372C2778609137 @default.
• W2048202372 hasConceptScore W2048202372C2779055221 @default.

• next