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• W2048202453 endingPage "1230" @default.
• W2048202453 startingPage "1220" @default.
• W2048202453 abstract "We describe a novel mechanism of viral RNA eradication by an oligodeoxynucleotide A (ODN A) directly in HIV virions. The ODN A consists of an antisense and a passenger strand, and was designed to target the polyp-urine tract (PPT) of HIV-1, a conserved region of the viral genome. It leads to HIV reverse transcriptase/ribonuclease H (RT/RNase H)-dependent degradation of the RNA in viral particles. Illimaquinone, a specific inhibitor of RNase H, activity of HIV RT/RNase H, prevents RNA cleavage. The effect of the ODN A is sequence-specific and the passenger strand is important, since a lack or alteration of this strand reduces the antiviral activity of the ODN. ODN A has a stronger antiviral effect compared to a control ODN CO, targeted to a site outside of the PPT. The pretreatment with ODN A strongly reduced the infectivity of virions in cell culture in the absence of any DNA carriers or detergents." @default.
• W2048202453 created "2016-06-24" @default.
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• W2048202453 date "2006-12-01" @default.
• W2048202453 modified "2023-09-23" @default.
• W2048202453 title "Short Partially Double-Stranded Oligodeoxynucleotide Induces Reverse Transcriptase/RNase H-Mediated Cleavage of HIV RNA and Contributes to Abrogation of Infectivity of Virions" @default.
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• W2048202453 doi "https://doi.org/10.1089/aid.2006.22.1220" @default.
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