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- W2048230048 abstract "Adult Sprague-Dawley rats were given a single dose of trimethyltin chloride (TMT). Three days following treatment, a neuronal alteration was observed in the CA3c pyramidal cell layer of hippocampus which was not accompanied by any apparent astrocyte reaction. At 1 as well as 2 weeks after treatment, a gliosis in hippocampus, piriform, and entorhinal cortices was detected by glial fibrillary acidic protein (GFAP) immunohistochemistry. Concomitant with the enhanced astrocytic GFAP, astrocytes were swollen and expressed immunoreactivity to vimentin and γ-aminobutyric acid (GABA). The astrocytic GABA immunoreactivity may reflect a trimethyltin-induced alteration in astrocyte phenotype, or alterations in compartmentalization and/or metabolism of GABA. © 1994 Wiley-Liss, Inc." @default.
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- W2048230048 date "1994-08-01" @default.
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- W2048230048 title "Trimethyltin-induced expression of GABA and vimentin immunoreactivities in astrocytes of the rat brain" @default.
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- W2048230048 doi "https://doi.org/10.1002/glia.440110410" @default.
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