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- W2048230841 endingPage "12860" @default.
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- W2048230841 abstract "The development of the structurally complex MDM2/p53 inhibitor AM-8553 was impeded by the low yield of the initial synthesis. A second generation synthesis is described that features a Noyori dynamic kinetic resolution, a highly diastereoselective allylation, and a novel oxazoline-assisted piperidinone forming reaction to provide AM-8553 in 35.6% yield and 11 steps." @default.
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- W2048230841 date "2012-07-16" @default.
- W2048230841 modified "2023-10-01" @default.
- W2048230841 title "An Expeditious Synthesis of the MDM2–p53 Inhibitor AM-8553" @default.
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- W2048230841 doi "https://doi.org/10.1021/ja305123v" @default.
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