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- W2048233485 abstract "Salmon calcitonin (sCT), a hormone shown to modulate calcium in the periphery modulated free, intracellular calcium, ([Ca++]i), in mouse brain synaptosomes as measured by changes in fura-2-mediated fluorescence. A 5-min incubation of synaptosomes with sCT produced an increase in the basal levels of [Ca++]i and an increase in KCl-stimulated levels of [Ca++]i. A 5-min pretreatment of mice with intraventricularly administered sCT antagonized morphine-induced antinociception in the tail-flick test, and facilitated naloxone antagonism of morphine. Conversely, pretreatment of synaptosomes for 1 h with salmon CT produced a decrease in depolarization-stimulated levels of [Ca++]i. The sCT-induced decrease in the stimulated rise in [Ca++]i at 1 h correlated temporally to sCT-induced antinociception in vivo. The effects of sCT in the electrically stimulated guinea pig ileum bioassay appeared to correlate to sCT effects in vivo. The data indicate that calcitonin may function as a neuromodulator via modulation of Ca++ within the central nervous system." @default.
- W2048233485 created "2016-06-24" @default.
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- W2048233485 date "1991-07-01" @default.
- W2048233485 modified "2023-09-27" @default.
- W2048233485 title "Salmon calcitonin-induced modulation of free intracellular calcium" @default.
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- W2048233485 doi "https://doi.org/10.1016/0091-3057(91)90140-w" @default.
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