Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048236483> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2048236483 endingPage "300" @default.
- W2048236483 startingPage "297" @default.
- W2048236483 abstract "The human lymphoblast cell line Jurkat is widely used as a model system for studying signal transduction pathways during lymphocyte activation. We report the presence of a potent endogenous inhibitor of protein kinase C (PKC) in the cytosolic fraction of Jurkat cells. This inhibitor is not diffusible and is thermolabile; it is assumed to be a protein. It was separated from PKC by ion-exchange chromatography on DEAE-cellulose. The inhibitory activity was partially reversed by increasing the concentration of the PKC substrate; increasing that of PKC activators (calcium and phospholipids) was without effect. PKC activity was inhibited by more than 90% in the crude cytosolic fraction but the inhibition could be completely reversed by diluting the cell extract. This inhibitory activity could not be detected in the cytosol from normal lymphocytes or from lymphoblasts from leukemic patients." @default.
- W2048236483 created "2016-06-24" @default.
- W2048236483 creator A5015699229 @default.
- W2048236483 creator A5027266939 @default.
- W2048236483 creator A5084408073 @default.
- W2048236483 date "1991-11-01" @default.
- W2048236483 modified "2023-10-18" @default.
- W2048236483 title "A protein kinase C inhibitory activity is present in the human T lymphoblast cell line Jurkat" @default.
- W2048236483 cites W1594758412 @default.
- W2048236483 cites W1995771395 @default.
- W2048236483 cites W2008509829 @default.
- W2048236483 cites W2010660119 @default.
- W2048236483 cites W2011246641 @default.
- W2048236483 cites W2077699484 @default.
- W2048236483 cites W2116954627 @default.
- W2048236483 cites W2399060042 @default.
- W2048236483 doi "https://doi.org/10.1016/0165-2478(91)90041-8" @default.
- W2048236483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1686872" @default.
- W2048236483 hasPublicationYear "1991" @default.
- W2048236483 type Work @default.
- W2048236483 sameAs 2048236483 @default.
- W2048236483 citedByCount "5" @default.
- W2048236483 crossrefType "journal-article" @default.
- W2048236483 hasAuthorship W2048236483A5015699229 @default.
- W2048236483 hasAuthorship W2048236483A5027266939 @default.
- W2048236483 hasAuthorship W2048236483A5084408073 @default.
- W2048236483 hasConcept C113842279 @default.
- W2048236483 hasConcept C153911025 @default.
- W2048236483 hasConcept C179464577 @default.
- W2048236483 hasConcept C181199279 @default.
- W2048236483 hasConcept C185592680 @default.
- W2048236483 hasConcept C195794163 @default.
- W2048236483 hasConcept C203014093 @default.
- W2048236483 hasConcept C2776090121 @default.
- W2048236483 hasConcept C2779155592 @default.
- W2048236483 hasConcept C54355233 @default.
- W2048236483 hasConcept C55493867 @default.
- W2048236483 hasConcept C62478195 @default.
- W2048236483 hasConcept C81885089 @default.
- W2048236483 hasConcept C86803240 @default.
- W2048236483 hasConcept C8891405 @default.
- W2048236483 hasConcept C95444343 @default.
- W2048236483 hasConcept C98539663 @default.
- W2048236483 hasConceptScore W2048236483C113842279 @default.
- W2048236483 hasConceptScore W2048236483C153911025 @default.
- W2048236483 hasConceptScore W2048236483C179464577 @default.
- W2048236483 hasConceptScore W2048236483C181199279 @default.
- W2048236483 hasConceptScore W2048236483C185592680 @default.
- W2048236483 hasConceptScore W2048236483C195794163 @default.
- W2048236483 hasConceptScore W2048236483C203014093 @default.
- W2048236483 hasConceptScore W2048236483C2776090121 @default.
- W2048236483 hasConceptScore W2048236483C2779155592 @default.
- W2048236483 hasConceptScore W2048236483C54355233 @default.
- W2048236483 hasConceptScore W2048236483C55493867 @default.
- W2048236483 hasConceptScore W2048236483C62478195 @default.
- W2048236483 hasConceptScore W2048236483C81885089 @default.
- W2048236483 hasConceptScore W2048236483C86803240 @default.
- W2048236483 hasConceptScore W2048236483C8891405 @default.
- W2048236483 hasConceptScore W2048236483C95444343 @default.
- W2048236483 hasConceptScore W2048236483C98539663 @default.
- W2048236483 hasIssue "3" @default.
- W2048236483 hasLocation W20482364831 @default.
- W2048236483 hasLocation W20482364832 @default.
- W2048236483 hasOpenAccess W2048236483 @default.
- W2048236483 hasPrimaryLocation W20482364831 @default.
- W2048236483 hasRelatedWork W1580727347 @default.
- W2048236483 hasRelatedWork W1695193253 @default.
- W2048236483 hasRelatedWork W1996540445 @default.
- W2048236483 hasRelatedWork W1998658648 @default.
- W2048236483 hasRelatedWork W2023520068 @default.
- W2048236483 hasRelatedWork W2039033625 @default.
- W2048236483 hasRelatedWork W2041913616 @default.
- W2048236483 hasRelatedWork W2048236483 @default.
- W2048236483 hasRelatedWork W2089978073 @default.
- W2048236483 hasRelatedWork W2157596541 @default.
- W2048236483 hasVolume "30" @default.
- W2048236483 isParatext "false" @default.
- W2048236483 isRetracted "false" @default.
- W2048236483 magId "2048236483" @default.
- W2048236483 workType "article" @default.