Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048236884> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2048236884 endingPage "S37" @default.
- W2048236884 startingPage "S36" @default.
- W2048236884 abstract "Hydrogen sulfide (H2S) is a signaling molecule that regulates diverse cell physiological process in several organs and systems including vascular and airway smooth muscle cell (SMC) contraction. Decreases in endogenous H2S synthesis have been associated with the development of cardiovascular diseases and asthma. Here we investigated the mechanism of airway SMC relaxation induced by H2S in small intrapulmonary airways using mouse lung slices and confocal and phase-contrast video microscopy. Exogenous H2S (100 μM) reversibly inhibited Ca2+ release and airway contraction evoked by inositol-1,4,5-trisphosphate (InsP3) uncaging in airway SMCs. Similarly, InsP3-evoked Ca2+ release and contraction was inhibited by endogenous H2S precursor L-cysteine (10 mM) but not by L-serine (10 mM) or either amino acid in the presence of DL-propargylglycine (PPG). Consistent with the inhibition of Ca2+ release through InsP3 receptors (InsP3R), H2S reversibly inhibited acetylcholine (ACh)-induced Ca2+ oscillations in airway SMCs. In addition, exogenous H2S and L-cysteine caused relaxation of airways pre-contracted with either ACh or 5-hydroxytriptamine (5-HT). The effects of H2S on InsP3-evoked Ca2+ release and contraction as well as on the relaxation of agonist-contracted airways were mimicked by the thiol-reducing agent dithiothreitol (DTT, 10 mM) and inhibited by the oxidizing agent diamide (30 μM). These studies indicate that H2S causes airway SMC relaxation by inhibiting Ca2+ release through InsP3R and consequent reduction of agonist-induced Ca2+ oscillations in SMCs. These results suggest a novel role for endogenously produced H2S that involves the modulation of InsP3-evoked Ca2+ release —a cell-signaling system of critical importance for many physiological and pathophysiological processes." @default.
- W2048236884 created "2016-06-24" @default.
- W2048236884 creator A5019879881 @default.
- W2048236884 creator A5061995831 @default.
- W2048236884 date "2013-09-01" @default.
- W2048236884 modified "2023-09-25" @default.
- W2048236884 title "P07 Hydrogen sulfide relaxes intrapulmonary airways by inhibiting Ca2+ release through InsP3 receptors and Ca2+ oscillations in smooth muscle cells" @default.
- W2048236884 doi "https://doi.org/10.1016/j.niox.2013.06.069" @default.
- W2048236884 hasPublicationYear "2013" @default.
- W2048236884 type Work @default.
- W2048236884 sameAs 2048236884 @default.
- W2048236884 citedByCount "0" @default.
- W2048236884 crossrefType "journal-article" @default.
- W2048236884 hasAuthorship W2048236884A5019879881 @default.
- W2048236884 hasAuthorship W2048236884A5061995831 @default.
- W2048236884 hasConcept C12554922 @default.
- W2048236884 hasConcept C134018914 @default.
- W2048236884 hasConcept C163415756 @default.
- W2048236884 hasConcept C16613235 @default.
- W2048236884 hasConcept C170493617 @default.
- W2048236884 hasConcept C181199279 @default.
- W2048236884 hasConcept C185592680 @default.
- W2048236884 hasConcept C2775910092 @default.
- W2048236884 hasConcept C2777824588 @default.
- W2048236884 hasConcept C2778938600 @default.
- W2048236884 hasConcept C2778988552 @default.
- W2048236884 hasConcept C2779201268 @default.
- W2048236884 hasConcept C55493867 @default.
- W2048236884 hasConcept C86803240 @default.
- W2048236884 hasConceptScore W2048236884C12554922 @default.
- W2048236884 hasConceptScore W2048236884C134018914 @default.
- W2048236884 hasConceptScore W2048236884C163415756 @default.
- W2048236884 hasConceptScore W2048236884C16613235 @default.
- W2048236884 hasConceptScore W2048236884C170493617 @default.
- W2048236884 hasConceptScore W2048236884C181199279 @default.
- W2048236884 hasConceptScore W2048236884C185592680 @default.
- W2048236884 hasConceptScore W2048236884C2775910092 @default.
- W2048236884 hasConceptScore W2048236884C2777824588 @default.
- W2048236884 hasConceptScore W2048236884C2778938600 @default.
- W2048236884 hasConceptScore W2048236884C2778988552 @default.
- W2048236884 hasConceptScore W2048236884C2779201268 @default.
- W2048236884 hasConceptScore W2048236884C55493867 @default.
- W2048236884 hasConceptScore W2048236884C86803240 @default.
- W2048236884 hasLocation W20482368841 @default.
- W2048236884 hasOpenAccess W2048236884 @default.
- W2048236884 hasPrimaryLocation W20482368841 @default.
- W2048236884 hasRelatedWork W1978653749 @default.
- W2048236884 hasRelatedWork W2051506977 @default.
- W2048236884 hasRelatedWork W2055074397 @default.
- W2048236884 hasRelatedWork W2067292543 @default.
- W2048236884 hasRelatedWork W2075552151 @default.
- W2048236884 hasRelatedWork W2089246574 @default.
- W2048236884 hasRelatedWork W2101193705 @default.
- W2048236884 hasRelatedWork W2223122503 @default.
- W2048236884 hasRelatedWork W274978290 @default.
- W2048236884 hasRelatedWork W2745179878 @default.
- W2048236884 hasVolume "31" @default.
- W2048236884 isParatext "false" @default.
- W2048236884 isRetracted "false" @default.
- W2048236884 magId "2048236884" @default.
- W2048236884 workType "article" @default.