FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048239644> ?p ?o ?g. }

• W2048239644 abstract "Abstract Background Hepatocellular carcinoma (HCC) in young subjects is rare but more devastating. We hypothesize that genes and etiological pathways are unique to young HCC (yHCC; ≤40 years old at diagnosis) patients. We therefore compared the gene expression profiles between yHCCs and HCCs from elderly patients. Results All 44 young HCCs (≤40 years old at the diagnosis; 23 cases in the training set while another 21 in the validation cohort) were positive for serum hepatitis B surface antigen (HBsAg), but negative for antibodies to hepatitis C virus (anti-HCV). All 48 elderly (>40 years old; 38 in the training set while another 10 in the validation cohort) HCC patients enrolled were also serum HBsAg positive and anti-HCV negative. Comparative genomics analysis was further performed for elucidating enriched or suppressed biological activities in different HCC subtypes. The yHCC group showed more macroscopic venous invasions (60.9% vs. 10.5%, p < 0.001), fewer associated cirrhosis (17.4% vs. 63.2%, p < 0.001), and distinct profiles of expressed genes, especially those related to DNA replication and repair. yHCCs possessed increased embryonic stem cell (ESC) traits and were more dedifferentiated. A 309-gene signature was obtained from two training cohorts and validated in another independent data set. The ILF3 ESC gene, which was previously reported in poorly differentiated breast cancers and bladder carcinomas, was also present in yHCCs. Genes associated with HCC suppression, including AR and ADRA1A, were less abundant in yHCCs. ESC genes were also more enriched in advanced HCCs from elderly patients. Conclusion This study revealed the molecular makeup of yHCC and the link between ESC traits and HCC subtypes. Findings in elderly tumors, therefore, cannot be simply extrapolated to young patients, and yHCC should be treated differently." @default.
• W2048239644 created "2016-06-24" @default.
• W2048239644 creator A5003842895 @default.
• W2048239644 creator A5028490633 @default.
• W2048239644 creator A5066607154 @default.
• W2048239644 creator A5074939317 @default.
• W2048239644 creator A5085389951 @default.
• W2048239644 creator A5085614261 @default.
• W2048239644 creator A5090069105 @default.
• W2048239644 date "2013-10-26" @default.
• W2048239644 modified "2023-10-14" @default.
• W2048239644 title "Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC" @default.
• W2048239644 cites W1524141331 @default.
• W2048239644 cites W1964368260 @default.
• W2048239644 cites W1984878894 @default.
• W2048239644 cites W1991712202 @default.
• W2048239644 cites W1994705023 @default.
• W2048239644 cites W2016438005 @default.
• W2048239644 cites W2020755558 @default.
• W2048239644 cites W2025496326 @default.
• W2048239644 cites W2027144233 @default.
• W2048239644 cites W2032689481 @default.
• W2048239644 cites W2037922362 @default.
• W2048239644 cites W2038767064 @default.
• W2048239644 cites W2039394834 @default.
• W2048239644 cites W2039845199 @default.
• W2048239644 cites W2049036892 @default.
• W2048239644 cites W2050339753 @default.
• W2048239644 cites W2054789893 @default.
• W2048239644 cites W2055428611 @default.
• W2048239644 cites W2058068487 @default.
• W2048239644 cites W2061826097 @default.
• W2048239644 cites W2073759231 @default.
• W2048239644 cites W2076043357 @default.
• W2048239644 cites W2076640757 @default.
• W2048239644 cites W2080782096 @default.
• W2048239644 cites W2094247251 @default.
• W2048239644 cites W2094776252 @default.
• W2048239644 cites W2098117487 @default.
• W2048239644 cites W2098800316 @default.
• W2048239644 cites W2104389844 @default.
• W2048239644 cites W2113108893 @default.
• W2048239644 cites W2125735075 @default.
• W2048239644 cites W2126697949 @default.
• W2048239644 cites W2133503086 @default.
• W2048239644 cites W2133738594 @default.
• W2048239644 cites W2134749269 @default.
• W2048239644 cites W2142443456 @default.
• W2048239644 cites W2151311897 @default.
• W2048239644 cites W4239180165 @default.
• W2048239644 doi "https://doi.org/10.1186/1471-2164-14-736" @default.
• W2048239644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3826595" @default.
• W2048239644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24160375" @default.
• W2048239644 hasPublicationYear "2013" @default.
• W2048239644 type Work @default.
• W2048239644 sameAs 2048239644 @default.
• W2048239644 citedByCount "41" @default.
• W2048239644 countsByYear W20482396442014 @default.
• W2048239644 countsByYear W20482396442015 @default.
• W2048239644 countsByYear W20482396442016 @default.
• W2048239644 countsByYear W20482396442018 @default.
• W2048239644 countsByYear W20482396442019 @default.
• W2048239644 countsByYear W20482396442020 @default.
• W2048239644 countsByYear W20482396442021 @default.
• W2048239644 countsByYear W20482396442022 @default.
• W2048239644 countsByYear W20482396442023 @default.
• W2048239644 crossrefType "journal-article" @default.
• W2048239644 hasAuthorship W2048239644A5003842895 @default.
• W2048239644 hasAuthorship W2048239644A5028490633 @default.
• W2048239644 hasAuthorship W2048239644A5066607154 @default.
• W2048239644 hasAuthorship W2048239644A5074939317 @default.
• W2048239644 hasAuthorship W2048239644A5085389951 @default.
• W2048239644 hasAuthorship W2048239644A5085614261 @default.
• W2048239644 hasAuthorship W2048239644A5090069105 @default.
• W2048239644 hasBestOaLocation W20482396441 @default.
• W2048239644 hasConcept C126322002 @default.
• W2048239644 hasConcept C143998085 @default.
• W2048239644 hasConcept C203014093 @default.
• W2048239644 hasConcept C2522874641 @default.
• W2048239644 hasConcept C2777214474 @default.
• W2048239644 hasConcept C2777410769 @default.
• W2048239644 hasConcept C2778019345 @default.
• W2048239644 hasConcept C2779314089 @default.
• W2048239644 hasConcept C2780593183 @default.
• W2048239644 hasConcept C502942594 @default.
• W2048239644 hasConcept C71924100 @default.
• W2048239644 hasConcept C72563966 @default.
• W2048239644 hasConcept C86803240 @default.
• W2048239644 hasConceptScore W2048239644C126322002 @default.
• W2048239644 hasConceptScore W2048239644C143998085 @default.
• W2048239644 hasConceptScore W2048239644C203014093 @default.
• W2048239644 hasConceptScore W2048239644C2522874641 @default.
• W2048239644 hasConceptScore W2048239644C2777214474 @default.
• W2048239644 hasConceptScore W2048239644C2777410769 @default.
• W2048239644 hasConceptScore W2048239644C2778019345 @default.
• W2048239644 hasConceptScore W2048239644C2779314089 @default.
• W2048239644 hasConceptScore W2048239644C2780593183 @default.
• W2048239644 hasConceptScore W2048239644C502942594 @default.
• W2048239644 hasConceptScore W2048239644C71924100 @default.
• W2048239644 hasConceptScore W2048239644C72563966 @default.

• next