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• W2048240839 endingPage "30" @default.
• W2048240839 startingPage "2" @default.
• W2048240839 abstract "Peptides are an increasingly important group of pharmaceuticals, positioned between classic small organic molecules and larger bio-molecules such as proteins. Currently, the peptide drug market is growing twice as fast as other drug markets, illustrating the increasing clinical as well as economical impact of this medicine group. Most peptides today are manufactured by solid-phase peptide synthesis (SPPS). This review will provide a structured overview of the most commonly observed peptide-related impurities in peptide medicines, encompassing the active pharmaceutical ingredients (API or drug substance) as well as the finished drug products. Not only is control of these peptide-related impurities and degradants critical for the already approved and clinically used peptide-drugs, these impurities also possess the capability of greatly influencing initial functionality studies during early drug discovery phases, possibly resulting in erroneous conclusions. The first group of peptide-related impurities is SPPS-related: deletion and insertion of amino acids are related to inefficient Fmoc-deprotection and excess use of amino acid reagents, respectively. Fmoc-deprotection can cause racemization of amino acid residues and thus diastereomeric impurities. Inefficient deprotection of amino acid side chains results into peptide-protection adducts. Furthermore, unprotected side chains can react with a variety of reagents used in the synthesis. Oxidation of amino acid side chains and dimeric-to-oligomeric impurities were also observed. Unwanted peptide counter ions such as trifluoroacetate, originating from the SPPS itself or from additional purification treatments, may also be present in the final peptide product. Contamination of the desired peptide product by other unrelated peptides was also seen, pointing out the lack of appropriate GMP. The second impurity group results from typical peptide degradation mechanisms such as β-elimination, diketopiperazine, pyroglutamate and succinimide formation. These SPPS- and degradation-related impurity types can also found in the finished peptide drug products, which can additionally contain a third group of related impurities, i.e. the API–excipient degradation products." @default.
• W2048240839 created "2016-06-24" @default.
• W2048240839 creator A5001781287 @default.
• W2048240839 creator A5015528105 @default.
• W2048240839 creator A5017615853 @default.
• W2048240839 creator A5071470047 @default.
• W2048240839 creator A5089636529 @default.
• W2048240839 creator A5089956255 @default.
• W2048240839 date "2014-12-01" @default.
• W2048240839 modified "2023-10-14" @default.
• W2048240839 title "Related impurities in peptide medicines" @default.
• W2048240839 cites W114864666 @default.
• W2048240839 cites W1188919047 @default.
• W2048240839 cites W147179502 @default.
• W2048240839 cites W1497105779 @default.
• W2048240839 cites W1534259153 @default.
• W2048240839 cites W1568231313 @default.
• W2048240839 cites W1576453695 @default.
• W2048240839 cites W177931530 @default.
• W2048240839 cites W1860382351 @default.
• W2048240839 cites W1944789189 @default.
• W2048240839 cites W1965414380 @default.
• W2048240839 cites W1967228207 @default.
• W2048240839 cites W1967573518 @default.
• W2048240839 cites W1968340770 @default.
• W2048240839 cites W1970126457 @default.
• W2048240839 cites W1971546597 @default.
• W2048240839 cites W1971805933 @default.
• W2048240839 cites W1973770616 @default.
• W2048240839 cites W1975122435 @default.
• W2048240839 cites W1978298690 @default.
• W2048240839 cites W1981000246 @default.
• W2048240839 cites W1981308253 @default.
• W2048240839 cites W1982186905 @default.
• W2048240839 cites W1983638944 @default.
• W2048240839 cites W1986029555 @default.
• W2048240839 cites W1986267605 @default.
• W2048240839 cites W1986299453 @default.
• W2048240839 cites W1986531175 @default.
• W2048240839 cites W1987205935 @default.
• W2048240839 cites W1990264812 @default.
• W2048240839 cites W1991826635 @default.
• W2048240839 cites W1993316312 @default.
• W2048240839 cites W1995592436 @default.
• W2048240839 cites W1996402485 @default.
• W2048240839 cites W1997135213 @default.
• W2048240839 cites W1999213903 @default.
• W2048240839 cites W2000814339 @default.
• W2048240839 cites W2002287610 @default.
• W2048240839 cites W2003649314 @default.
• W2048240839 cites W2003793745 @default.
• W2048240839 cites W2004110373 @default.
• W2048240839 cites W2004569128 @default.
• W2048240839 cites W2006885501 @default.
• W2048240839 cites W2007879544 @default.
• W2048240839 cites W2008630616 @default.
• W2048240839 cites W2009787851 @default.
• W2048240839 cites W2011011081 @default.
• W2048240839 cites W2011492538 @default.
• W2048240839 cites W2013228860 @default.
• W2048240839 cites W2013827851 @default.
• W2048240839 cites W2014004674 @default.
• W2048240839 cites W2015348374 @default.
• W2048240839 cites W2015961921 @default.
• W2048240839 cites W2016585194 @default.
• W2048240839 cites W2022505591 @default.
• W2048240839 cites W2023319785 @default.
• W2048240839 cites W2026350442 @default.
• W2048240839 cites W2030450209 @default.
• W2048240839 cites W2030666044 @default.
• W2048240839 cites W2032355807 @default.
• W2048240839 cites W2034130354 @default.
• W2048240839 cites W2035218123 @default.
• W2048240839 cites W2036288444 @default.
• W2048240839 cites W2036354205 @default.
• W2048240839 cites W2036371444 @default.
• W2048240839 cites W2036790465 @default.
• W2048240839 cites W2039041002 @default.
• W2048240839 cites W2041154310 @default.
• W2048240839 cites W2041163117 @default.
• W2048240839 cites W2042517193 @default.
• W2048240839 cites W2044235886 @default.
• W2048240839 cites W2045667587 @default.
• W2048240839 cites W2050000500 @default.
• W2048240839 cites W2051118435 @default.
• W2048240839 cites W2051479927 @default.
• W2048240839 cites W2053043974 @default.
• W2048240839 cites W2053316491 @default.
• W2048240839 cites W2053381899 @default.
• W2048240839 cites W2053893413 @default.
• W2048240839 cites W2055224716 @default.
• W2048240839 cites W2055394047 @default.
• W2048240839 cites W2055422378 @default.
• W2048240839 cites W2055685336 @default.
• W2048240839 cites W2057874769 @default.
• W2048240839 cites W2059643569 @default.
• W2048240839 cites W2059811616 @default.
• W2048240839 cites W2062228103 @default.

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