FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048243716> ?p ?o ?g. }

• W2048243716 endingPage "F954" @default.
• W2048243716 startingPage "F948" @default.
• W2048243716 abstract "Isoproterenol stimulates H-K-ATPase activity in rat cortical collecting duct beta-intercalated cells through a PKA-dependent pathway. This study aimed at determining the signaling pathway underlying this effect. H-K-ATPase activity was determined in microdissected collecting ducts preincubated with or without specific inhibitors or antibodies against intracellular signaling proteins. Transient cell membrane permeabilization with streptolysin-O allowed intracellular access to antibodies. Isoproterenol increased phosphorylation of ERK in a PKA-dependent manner, and inhibition of the ERK phosphorylation prevented the stimulation of H-K-ATPase. Antibodies against the monomeric G protein Ras or the kinase Raf-1 curtailed the stimulation of H-K-ATPase by isoproterenol, whereas antibodies against the related proteins Rap-1 and B-Raf had no effect. Pertussis toxin and inhibition of tyrosine kinases with genistein also curtailed isoproterenol-induced stimulation of H-K-ATPase. It is proposed that activation of PKA by isoproterenol induces the phosphorylation of beta-adrenergic receptors and the switch from G(s) to G(i) coupling. In turn, betagamma-subunits released from G(i) would activate a tyrosine kinase-Ras-Raf-1 pathway, leading to the activation of ERK1/2 and of H-K-ATPase." @default.
• W2048243716 created "2016-06-24" @default.
• W2048243716 creator A5042526579 @default.
• W2048243716 creator A5051436796 @default.
• W2048243716 creator A5057930194 @default.
• W2048243716 creator A5061248800 @default.
• W2048243716 creator A5089240562 @default.
• W2048243716 date "2003-05-01" @default.
• W2048243716 modified "2023-09-27" @default.
• W2048243716 title "Mechanism of activation of ERK and H-K-ATPase by isoproterenol in rat cortical collecting duct" @default.
• W2048243716 cites W115402903 @default.
• W2048243716 cites W1499870879 @default.
• W2048243716 cites W1769585641 @default.
• W2048243716 cites W1885709862 @default.
• W2048243716 cites W1983837942 @default.
• W2048243716 cites W1991290648 @default.
• W2048243716 cites W2000227813 @default.
• W2048243716 cites W2011694331 @default.
• W2048243716 cites W2045876058 @default.
• W2048243716 cites W2066235505 @default.
• W2048243716 cites W2066278140 @default.
• W2048243716 cites W2066696278 @default.
• W2048243716 cites W2067581172 @default.
• W2048243716 cites W2078381037 @default.
• W2048243716 cites W2078792023 @default.
• W2048243716 cites W2082889823 @default.
• W2048243716 cites W2086262311 @default.
• W2048243716 cites W2110487056 @default.
• W2048243716 cites W2123022315 @default.
• W2048243716 cites W2126589234 @default.
• W2048243716 cites W2166820437 @default.
• W2048243716 cites W2184972429 @default.
• W2048243716 cites W2226253996 @default.
• W2048243716 cites W2305532933 @default.
• W2048243716 cites W2321764511 @default.
• W2048243716 cites W2333371078 @default.
• W2048243716 cites W2356432090 @default.
• W2048243716 cites W2408792254 @default.
• W2048243716 cites W2409219257 @default.
• W2048243716 doi "https://doi.org/10.1152/ajprenal.00394.2002" @default.
• W2048243716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12676735" @default.
• W2048243716 hasPublicationYear "2003" @default.
• W2048243716 type Work @default.
• W2048243716 sameAs 2048243716 @default.
• W2048243716 citedByCount "25" @default.
• W2048243716 countsByYear W20482437162012 @default.
• W2048243716 countsByYear W20482437162013 @default.
• W2048243716 countsByYear W20482437162016 @default.
• W2048243716 countsByYear W20482437162019 @default.
• W2048243716 countsByYear W20482437162020 @default.
• W2048243716 countsByYear W20482437162021 @default.
• W2048243716 countsByYear W20482437162022 @default.
• W2048243716 countsByYear W20482437162023 @default.
• W2048243716 crossrefType "journal-article" @default.
• W2048243716 hasAuthorship W2048243716A5042526579 @default.
• W2048243716 hasAuthorship W2048243716A5051436796 @default.
• W2048243716 hasAuthorship W2048243716A5057930194 @default.
• W2048243716 hasAuthorship W2048243716A5061248800 @default.
• W2048243716 hasAuthorship W2048243716A5089240562 @default.
• W2048243716 hasConcept C11960822 @default.
• W2048243716 hasConcept C126322002 @default.
• W2048243716 hasConcept C134018914 @default.
• W2048243716 hasConcept C153911025 @default.
• W2048243716 hasConcept C184235292 @default.
• W2048243716 hasConcept C185592680 @default.
• W2048243716 hasConcept C24998067 @default.
• W2048243716 hasConcept C2777553839 @default.
• W2048243716 hasConcept C42362537 @default.
• W2048243716 hasConcept C49773422 @default.
• W2048243716 hasConcept C57074206 @default.
• W2048243716 hasConcept C62478195 @default.
• W2048243716 hasConcept C71924100 @default.
• W2048243716 hasConcept C79879829 @default.
• W2048243716 hasConcept C80631254 @default.
• W2048243716 hasConcept C86803240 @default.
• W2048243716 hasConcept C95444343 @default.
• W2048243716 hasConcept C97029542 @default.
• W2048243716 hasConceptScore W2048243716C11960822 @default.
• W2048243716 hasConceptScore W2048243716C126322002 @default.
• W2048243716 hasConceptScore W2048243716C134018914 @default.
• W2048243716 hasConceptScore W2048243716C153911025 @default.
• W2048243716 hasConceptScore W2048243716C184235292 @default.
• W2048243716 hasConceptScore W2048243716C185592680 @default.
• W2048243716 hasConceptScore W2048243716C24998067 @default.
• W2048243716 hasConceptScore W2048243716C2777553839 @default.
• W2048243716 hasConceptScore W2048243716C42362537 @default.
• W2048243716 hasConceptScore W2048243716C49773422 @default.
• W2048243716 hasConceptScore W2048243716C57074206 @default.
• W2048243716 hasConceptScore W2048243716C62478195 @default.
• W2048243716 hasConceptScore W2048243716C71924100 @default.
• W2048243716 hasConceptScore W2048243716C79879829 @default.
• W2048243716 hasConceptScore W2048243716C80631254 @default.
• W2048243716 hasConceptScore W2048243716C86803240 @default.
• W2048243716 hasConceptScore W2048243716C95444343 @default.
• W2048243716 hasConceptScore W2048243716C97029542 @default.
• W2048243716 hasIssue "5" @default.
• W2048243716 hasLocation W20482437161 @default.
• W2048243716 hasLocation W20482437162 @default.

• next