Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048269882> ?p ?o ?g. }
- W2048269882 endingPage "737" @default.
- W2048269882 startingPage "730" @default.
- W2048269882 abstract "Abstract Identifying the gene expression changes induced by hepatic encephalopathy (HE) leads to a better understanding of the molecular mechanisms of HE‐induced neurological dysfunction. Using GeneChip® and real‐time PCR, the present study evaluated the gene expression profile of rat cerebral cortex at 4 weeks after portacaval shunting. Among 1,263 transcripts represented on the chip, mRNA levels of 31 transcripts were altered (greater than twofold; 16 increased and 15 decreased) in the portacaval shunted (PCS) rat compared to sham control. Changes observed by GeneChip® analysis were confirmed for 20 transcripts (8 increased, 7 decreased, and 5 unchanged in PCS rat brain) by real‐time PCR. Neurotransmitter receptors, transporters, and members of the second messenger signal transduction are the major groups of genes altered in PCS rat brain. Of importance was that the increased heme oxygenase‐1 and decreased Cu,Zn‐superoxide dismutase expression observed raise the possibility of oxidative stress playing a pathogenic role in chronic HE. © 2002 Wiley‐Liss, Inc." @default.
- W2048269882 created "2016-06-24" @default.
- W2048269882 creator A5038845488 @default.
- W2048269882 creator A5061022602 @default.
- W2048269882 creator A5069545143 @default.
- W2048269882 creator A5073442975 @default.
- W2048269882 creator A5087453054 @default.
- W2048269882 date "2002-05-01" @default.
- W2048269882 modified "2023-10-16" @default.
- W2048269882 title "GeneChip® analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats" @default.
- W2048269882 cites W128171387 @default.
- W2048269882 cites W1523342958 @default.
- W2048269882 cites W1597754875 @default.
- W2048269882 cites W1920777925 @default.
- W2048269882 cites W1942398216 @default.
- W2048269882 cites W1967939120 @default.
- W2048269882 cites W1975350144 @default.
- W2048269882 cites W1976250238 @default.
- W2048269882 cites W1977222362 @default.
- W2048269882 cites W1978771885 @default.
- W2048269882 cites W1979402178 @default.
- W2048269882 cites W1980844178 @default.
- W2048269882 cites W1988412995 @default.
- W2048269882 cites W1991418670 @default.
- W2048269882 cites W1992091811 @default.
- W2048269882 cites W1993237562 @default.
- W2048269882 cites W1995409393 @default.
- W2048269882 cites W1996184623 @default.
- W2048269882 cites W2002731078 @default.
- W2048269882 cites W2007024508 @default.
- W2048269882 cites W2010289579 @default.
- W2048269882 cites W2011318492 @default.
- W2048269882 cites W2013290120 @default.
- W2048269882 cites W2020370096 @default.
- W2048269882 cites W2020660959 @default.
- W2048269882 cites W2024630514 @default.
- W2048269882 cites W2034623287 @default.
- W2048269882 cites W2036776986 @default.
- W2048269882 cites W2039208700 @default.
- W2048269882 cites W2041867742 @default.
- W2048269882 cites W2042537928 @default.
- W2048269882 cites W2045532751 @default.
- W2048269882 cites W2057935415 @default.
- W2048269882 cites W2059045696 @default.
- W2048269882 cites W2063120515 @default.
- W2048269882 cites W2068898323 @default.
- W2048269882 cites W2070104907 @default.
- W2048269882 cites W2071364408 @default.
- W2048269882 cites W2074091969 @default.
- W2048269882 cites W2075472484 @default.
- W2048269882 cites W2079995698 @default.
- W2048269882 cites W2080691098 @default.
- W2048269882 cites W2081088012 @default.
- W2048269882 cites W2081350209 @default.
- W2048269882 cites W2090055590 @default.
- W2048269882 cites W2095920121 @default.
- W2048269882 cites W2098152807 @default.
- W2048269882 cites W2104504192 @default.
- W2048269882 cites W2150926065 @default.
- W2048269882 cites W2151492430 @default.
- W2048269882 cites W2166430215 @default.
- W2048269882 cites W2167875973 @default.
- W2048269882 cites W2171243114 @default.
- W2048269882 cites W2280899070 @default.
- W2048269882 cites W2331081711 @default.
- W2048269882 cites W240309487 @default.
- W2048269882 cites W4232848602 @default.
- W2048269882 cites W4233182253 @default.
- W2048269882 cites W5712728 @default.
- W2048269882 doi "https://doi.org/10.1002/jnr.10268" @default.
- W2048269882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12111833" @default.
- W2048269882 hasPublicationYear "2002" @default.
- W2048269882 type Work @default.
- W2048269882 sameAs 2048269882 @default.
- W2048269882 citedByCount "75" @default.
- W2048269882 countsByYear W20482698822012 @default.
- W2048269882 countsByYear W20482698822013 @default.
- W2048269882 countsByYear W20482698822014 @default.
- W2048269882 countsByYear W20482698822015 @default.
- W2048269882 countsByYear W20482698822018 @default.
- W2048269882 countsByYear W20482698822019 @default.
- W2048269882 countsByYear W20482698822020 @default.
- W2048269882 crossrefType "journal-article" @default.
- W2048269882 hasAuthorship W2048269882A5038845488 @default.
- W2048269882 hasAuthorship W2048269882A5061022602 @default.
- W2048269882 hasAuthorship W2048269882A5069545143 @default.
- W2048269882 hasAuthorship W2048269882A5073442975 @default.
- W2048269882 hasAuthorship W2048269882A5087453054 @default.
- W2048269882 hasConcept C104317684 @default.
- W2048269882 hasConcept C105580179 @default.
- W2048269882 hasConcept C126322002 @default.
- W2048269882 hasConcept C134018914 @default.
- W2048269882 hasConcept C150194340 @default.
- W2048269882 hasConcept C153911025 @default.
- W2048269882 hasConcept C156927020 @default.
- W2048269882 hasConcept C170493617 @default.
- W2048269882 hasConcept C181199279 @default.
- W2048269882 hasConcept C2775838275 @default.