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• W2048271100 abstract "Recent studies indicate that the corpus luteum (CL) may be a source of prostaglandin F2alpha (PGF2alpha) for regression. We investigated expression of mRNA and protein for prostaglandin G/H synthase (PGHS) in the CL of immature superovulated rats following administration of PGF2alpha. We observed an increase in mRNA for PGHS-2, the induced isoform, at 1 h and protein at 8 and 24 h after treatment. One hour after PGF2alpha, there was also a progressive decrease in plasma progesterone concentration. There were no changes, however, in expression of PGHS-1, the constitutive isoform, over the 24 h sampling period. These results indicate that PGHS-2 increases following PGF2alpha treatment and that expression of this enzyme in the rat CL may contribute to the luteolytic mechanism." @default.
• W2048271100 created "2016-06-24" @default.
• W2048271100 creator A5018258250 @default.
• W2048271100 creator A5036456439 @default.
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• W2048271100 date "2002-09-01" @default.
• W2048271100 modified "2023-09-25" @default.
• W2048271100 title "Treatment with prostaglandin F2α increases expression of prostaglandin synthase-2 in the rat corpus luteum" @default.
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• W2048271100 doi "https://doi.org/10.1016/s0090-6980(02)00062-x" @default.
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