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- W2048277264 abstract "Epithelial cells are pivotal in the separation of the body from the outside environment. Orally administered drugs must pass across epithelial cell sheets, and most pathological organisms invade the body through epithelial cells. Tight junctions (TJs) are sealing complexes between adjacent epithelial cells. Modulation of TJ components is a potent strategy for increasing absorption. Inflammation often causes disruption of the TJ barrier. Molecular imaging technology has enabled elucidation of the dynamics of TJs. Molecular pathological analysis has shown the relationship between TJ components and molecular pathological conditions. In this article, we discuss TJ-targeted drug development over the past 2 years." @default.
- W2048277264 created "2016-06-24" @default.
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- W2048277264 date "2012-07-01" @default.
- W2048277264 modified "2023-09-24" @default.
- W2048277264 title "Pathological changes in tight junctions and potential applications into therapies" @default.
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- W2048277264 doi "https://doi.org/10.1016/j.drudis.2012.02.014" @default.
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