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• W2048282205 abstract "Dendritic cells (DC) represent the most potent antigen presenting cells and induce efficient cytotoxic T lymphocyte (CTL) responses against viral infections. Targeting antigens (Ag) to receptors on DCs is a promising strategy to enhance antitumor and antiviral immune responses induced by DCs. Here, we investigated the potential of CD11c-specific single-chain fragments (scFv) fused to an immunodominant peptide of Friend retrovirus for induction of virus-specific T cell responses by DCs. In vitro CD11c-specific scFv selectively targeted viral antigens to DCs and thereby significantly improved the activation of virus-specific T cells. In vaccination experiments DCs loaded with viral Ag targeted to CD11c provided improved rejection of FV-derived tumors and efficiently primed virus-specific CTL responses after virus challenge. Since the induction of strong virus-specific T cell responses is critical in viral infections, CD11c targeted protein vaccines might provide means to enhance the cellular immune response to prophylactic or therapeutic levels." @default.
• W2048282205 created "2016-06-24" @default.
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• W2048282205 date "2012-09-17" @default.
• W2048282205 modified "2023-10-18" @default.
• W2048282205 title "Targeting Viral Antigens to CD11c on Dendritic Cells Induces Retrovirus-Specific T Cell Responses" @default.
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• W2048282205 doi "https://doi.org/10.1371/journal.pone.0045102" @default.
• W2048282205 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3444473" @default.
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