Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048282904> ?p ?o ?g. }
- W2048282904 endingPage "24" @default.
- W2048282904 startingPage "14" @default.
- W2048282904 abstract "Defects in autophagy have been linked to a wide range of medical illnesses, including cancer as well as infectious, neurodegenerative, inflammatory, and metabolic diseases. These observations have led to the hypothesis that autophagy inducers may prevent or treat certain clinical conditions. Lifestyle and nutritional factors, such as exercise and caloric restriction, may exert their known health benefits through the autophagy pathway. Several currently available FDA-approved drugs have been shown to enhance autophagy, and this autophagy-enhancing action may be repurposed for use in novel clinical indications. The development of new drugs that are designed to be more selective inducers of autophagy function in target organs is expected to maximize clinical benefits while minimizing toxicity. This Review summarizes the rationale and current approaches for developing autophagy inducers in medicine, the factors to be considered in defining disease targets for such therapy, and the potential benefits of such treatment for human health." @default.
- W2048282904 created "2016-06-24" @default.
- W2048282904 creator A5007431268 @default.
- W2048282904 creator A5015807309 @default.
- W2048282904 creator A5051700932 @default.
- W2048282904 date "2015-01-02" @default.
- W2048282904 modified "2023-10-06" @default.
- W2048282904 title "Development of autophagy inducers in clinical medicine" @default.
- W2048282904 cites W1523693806 @default.
- W2048282904 cites W1883048423 @default.
- W2048282904 cites W1964552652 @default.
- W2048282904 cites W1970661950 @default.
- W2048282904 cites W1973472942 @default.
- W2048282904 cites W1975200363 @default.
- W2048282904 cites W1975510193 @default.
- W2048282904 cites W1975915706 @default.
- W2048282904 cites W1976761774 @default.
- W2048282904 cites W1979681812 @default.
- W2048282904 cites W1979783084 @default.
- W2048282904 cites W1980496079 @default.
- W2048282904 cites W1981950106 @default.
- W2048282904 cites W1985124617 @default.
- W2048282904 cites W1985484942 @default.
- W2048282904 cites W1987566768 @default.
- W2048282904 cites W1987769185 @default.
- W2048282904 cites W1988044873 @default.
- W2048282904 cites W1988626880 @default.
- W2048282904 cites W1990204346 @default.
- W2048282904 cites W1990411057 @default.
- W2048282904 cites W1991418047 @default.
- W2048282904 cites W1991692801 @default.
- W2048282904 cites W1992881494 @default.
- W2048282904 cites W1994807972 @default.
- W2048282904 cites W1994823455 @default.
- W2048282904 cites W1995418930 @default.
- W2048282904 cites W1999801453 @default.
- W2048282904 cites W1999998145 @default.
- W2048282904 cites W2006393063 @default.
- W2048282904 cites W2007346295 @default.
- W2048282904 cites W2009225398 @default.
- W2048282904 cites W2012958260 @default.
- W2048282904 cites W2015808257 @default.
- W2048282904 cites W2017322442 @default.
- W2048282904 cites W2020701385 @default.
- W2048282904 cites W2021178651 @default.
- W2048282904 cites W2022020884 @default.
- W2048282904 cites W2022177282 @default.
- W2048282904 cites W2024421162 @default.
- W2048282904 cites W2024782183 @default.
- W2048282904 cites W2028536701 @default.
- W2048282904 cites W2029164073 @default.
- W2048282904 cites W2033234733 @default.
- W2048282904 cites W2033606928 @default.
- W2048282904 cites W2040328910 @default.
- W2048282904 cites W2043045955 @default.
- W2048282904 cites W2043270577 @default.
- W2048282904 cites W2047341797 @default.
- W2048282904 cites W2048030072 @default.
- W2048282904 cites W2048494900 @default.
- W2048282904 cites W2052101545 @default.
- W2048282904 cites W2052282580 @default.
- W2048282904 cites W2053585837 @default.
- W2048282904 cites W2054203136 @default.
- W2048282904 cites W2055971882 @default.
- W2048282904 cites W2060522415 @default.
- W2048282904 cites W2064876347 @default.
- W2048282904 cites W2065031087 @default.
- W2048282904 cites W2066209509 @default.
- W2048282904 cites W2067692987 @default.
- W2048282904 cites W2071221374 @default.
- W2048282904 cites W2076649068 @default.
- W2048282904 cites W2076683315 @default.
- W2048282904 cites W2077397852 @default.
- W2048282904 cites W2077556440 @default.
- W2048282904 cites W2078903854 @default.
- W2048282904 cites W2081057817 @default.
- W2048282904 cites W2082229119 @default.
- W2048282904 cites W2082476985 @default.
- W2048282904 cites W2082651238 @default.
- W2048282904 cites W2086943351 @default.
- W2048282904 cites W2089230333 @default.
- W2048282904 cites W2091046505 @default.
- W2048282904 cites W2091619946 @default.
- W2048282904 cites W2093476486 @default.
- W2048282904 cites W2094898345 @default.
- W2048282904 cites W2095240020 @default.
- W2048282904 cites W2096853390 @default.
- W2048282904 cites W2096912149 @default.
- W2048282904 cites W2097144541 @default.
- W2048282904 cites W2099130114 @default.
- W2048282904 cites W2105058961 @default.
- W2048282904 cites W2109034822 @default.
- W2048282904 cites W2111567059 @default.
- W2048282904 cites W2112329697 @default.
- W2048282904 cites W2113206573 @default.
- W2048282904 cites W2113698463 @default.
- W2048282904 cites W2116690246 @default.
- W2048282904 cites W2121104406 @default.