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- W2048292043 abstract "Hormone profile end pelvic ultrasonography were studied in 41 girls with premature thelarche aged 21 .2 ± 9.7 months and in 39 non affected conrrol girls of the same age and social status. Estrogenic contaminants were looked for both in girls sera and in poultry samples through serum and tissue levels of zearalenone and diethilbestrol. Total estrogenic activity was measured by radioreceptor assay. Basal serum levels or LH, FSH, prolactine and estradiol [E2] were not different between both groups. Total estrogenic activity was significantly higher in girls with thelarche [201 ± 102 vs 78 ± 20 pg E2 eauivalent), turning later to sim'lar levels than in controls in five patients in which thelarche eventually subsided. After LHRH greater FSH than LH peak response was observed (28.7 ± 1 7.5 Up/ml vs 5, ~ ± 2.7 Uu/m!|. No differences were detected in uterine size and squeletal maturation, but a greater mean ovarian volume was seen in patients with thelarquia. No estrogenic contaminants v/ere detected in poultry samples. Partial activation of ihe hypothalamus-pituitary-axis, mainly through FSH secretion, might thus be the responsible of ovarian secretion of E2 or another substance wtn estrogenic action." @default.
- W2048292043 created "2016-06-24" @default.
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- W2048292043 date "1995-04-01" @default.
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- W2048292043 title "Telarquía prematura: Aumento de la actividad estrogénica total en el plasma" @default.
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- W2048292043 doi "https://doi.org/10.4067/s0370-41061995000200001" @default.
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