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- W2048306228 abstract "Milk ejection and milk removal is considerably influenced by the sympathetic nervous system. Stimulation of α-adrenergic receptors by administration of α-adrenergic agonists inhibits alveolar milk ejection and milk removal in dairy cows due to smooth muscle contraction (Blum et al. 1989; Bruckmaier et al. 1991). However, contraction of the teat in response to α-adrenergic receptor stimulation has no influence on milk flow as long as milk is available in the cistern (Bruckmaier et al. 1997). Therefore, α-adrenergic stimulation causes inhibition of transport of alveolar milk into the cistern. On the contrary, the stimulation of β-adrenergic receptors facilitates milk ejection and milk removal in dairy cows (Bernabé & Peeters, 1980; Bruckmaier et al. 1991) because of muscle relaxation. Therefore, the distribution of α- and β-adrenergic receptors plays an important role in the milkability of dairy cows. However, from these in vivo studies it is not possible to distinguish between the different α 1 - and α 2 - and β 2 -receptor subtypes owing to the non-specific nature of the pharmacological agents used. To date, the precise tissue distribution of these different subtypes, in bovine mammary tissue, is unknown. Using molecular techniques, we were interested in the expression of genes that encode α 1c and β 2 as a preliminary study towards the understanding of noradrenergic receptor-gene expression and regulation in this important system. In addition, α 1c - and β 2 -adrenergic receptors were determined in front and rear quarters of the mammary gland to investigate differences in receptor distribution within the udder and possible relations between adrenergic receptor distribution and the higher milk flow rates in rear than in front quarters (Rothenanger et al. 1995)." @default.
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- W2048306228 date "2001-11-01" @default.
- W2048306228 modified "2023-09-26" @default.
- W2048306228 title "α1c- and β2-adrenergic receptor mRNA distribution in the bovine mammary gland detected by competitive RT-PCR" @default.
- W2048306228 doi "https://doi.org/10.1017/s0022029901005076" @default.
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