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- W2048307732 abstract "Abstract To define more clearly the mechanisms operate in the transport of iron by intestinal mucosa, the short-circuit technique has been applied to isolated sections of small intestine of rat. Parallel experiments have been carried out in vivo using ligated sections of the small intestine in the intact rat. Low-molecular-weight chelates are necessary to maintain iron in a soluble and permeable from. Although the rate of mucosal to serosal transport appears to be directly dependent upon the concentration of iron chelate presented to the cell, a membrane-bound facilitating carrier also participates in the process. Evidence is presented for an active serosal to mucosal component for iron transport. Metabolic inhibitors, low temperatures and anaerobiosis abolish the net serosal to mucosal flux. The chemical nature of the chelate directly affects the rate of transmembrane transport as well as the tissue distribution of the iron molecule. Iron deficiency anemia causes both a decrease in the serosal to mucosal iron flux and an increase in the mucosal to serosal component. These factors appear to be responsible for the enhanced uptake of iron observed in anemic animals." @default.
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- W2048307732 date "1967-11-01" @default.
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- W2048307732 title "The transport of iron by rat intestine" @default.
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- W2048307732 doi "https://doi.org/10.1016/0005-2736(67)90068-5" @default.
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