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- W2048314102 abstract "The spalt (sal) family is a class of evolutionarily conserved genes originally identified in Drosophila as homeotic genes required for embryonic development. In vertebrates, the expression of sal-like 4 (SALL4) is specifically enriched in both embryonic and adult stem/stem-like cells. SALL4 is a master regulator that contributes to cell stemness in biological development and tumor growth. Thus, Sall4 has emerged as a target for gene therapy. In addition, numerous mutations affecting the Sall4 gene have been discovered and clinically linked to a series of congenital abnormalities, such as Duane/Duane-related syndromes, ventricular septal defect and premature ovarian failure. This review delineates the underlying mechanisms of key functions of SALL4 and its use as a target for gene therapy. Finally, I summarize and discuss advances made on the application of Sall4 and its functions in diagnostics and treatments for human diseases. Keywords: Cancer, Duane syndrome, embryonic development, hematopoiesis, Sall4, stem cell." @default.
- W2048314102 created "2016-06-24" @default.
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- W2048314102 date "2014-08-25" @default.
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- W2048314102 title "SALL4: Engine of Cell Stemness" @default.
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- W2048314102 doi "https://doi.org/10.2174/1566523214666140825125138" @default.
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