Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048320237> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2048320237 endingPage "44" @default.
- W2048320237 startingPage "43" @default.
- W2048320237 abstract "CD40 ligand (CD40L) delivers a contact-dependent signal to B cells which, in the presence of interleukin (IL)-4, drives immunoglobulin isotype switching to IgE. CD40L expression in T cells is transient, requires activation of protein kinase C and a rise in intracellular calcium concentration ([Ca2+]i), and is inhibited by cyclosporin A (CsA). CsA also inhibited T-cell-dependent IL-4-driven IgE synthesis. We have found that expression of CD40L is developmentally regulated. Expression of CD40L was restricted to mature single-positive thymocytes which, in the presence of IL-4, were capable of inducing B cells to undergo IgE isotype switching. CD40L expression was severely decreased in cord blood lymphocytes and was associated with a severely decreased ability to undergo T-cell-dependent IgE isotype switching." @default.
- W2048320237 created "2016-06-24" @default.
- W2048320237 creator A5048379219 @default.
- W2048320237 creator A5069747438 @default.
- W2048320237 creator A5081954803 @default.
- W2048320237 date "1995-01-01" @default.
- W2048320237 modified "2023-09-23" @default.
- W2048320237 title "Expression of the CD40 Ligand in T Lymphocytes and Induction of IgE Isotype Switching" @default.
- W2048320237 cites W1977687771 @default.
- W2048320237 cites W1984754431 @default.
- W2048320237 cites W2150278877 @default.
- W2048320237 cites W2160410700 @default.
- W2048320237 doi "https://doi.org/10.1159/000236925" @default.
- W2048320237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7542098" @default.
- W2048320237 hasPublicationYear "1995" @default.
- W2048320237 type Work @default.
- W2048320237 sameAs 2048320237 @default.
- W2048320237 citedByCount "11" @default.
- W2048320237 countsByYear W20483202372014 @default.
- W2048320237 countsByYear W20483202372015 @default.
- W2048320237 countsByYear W20483202372019 @default.
- W2048320237 countsByYear W20483202372021 @default.
- W2048320237 crossrefType "journal-article" @default.
- W2048320237 hasAuthorship W2048320237A5048379219 @default.
- W2048320237 hasAuthorship W2048320237A5069747438 @default.
- W2048320237 hasAuthorship W2048320237A5081954803 @default.
- W2048320237 hasBestOaLocation W20483202371 @default.
- W2048320237 hasConcept C137756551 @default.
- W2048320237 hasConcept C141105273 @default.
- W2048320237 hasConcept C153911025 @default.
- W2048320237 hasConcept C154317977 @default.
- W2048320237 hasConcept C159654299 @default.
- W2048320237 hasConcept C185592680 @default.
- W2048320237 hasConcept C191732599 @default.
- W2048320237 hasConcept C202751555 @default.
- W2048320237 hasConcept C203014093 @default.
- W2048320237 hasConcept C2776090121 @default.
- W2048320237 hasConcept C2777991845 @default.
- W2048320237 hasConcept C2778453870 @default.
- W2048320237 hasConcept C2778690821 @default.
- W2048320237 hasConcept C39347974 @default.
- W2048320237 hasConcept C542903549 @default.
- W2048320237 hasConcept C55493867 @default.
- W2048320237 hasConcept C86803240 @default.
- W2048320237 hasConcept C8891405 @default.
- W2048320237 hasConceptScore W2048320237C137756551 @default.
- W2048320237 hasConceptScore W2048320237C141105273 @default.
- W2048320237 hasConceptScore W2048320237C153911025 @default.
- W2048320237 hasConceptScore W2048320237C154317977 @default.
- W2048320237 hasConceptScore W2048320237C159654299 @default.
- W2048320237 hasConceptScore W2048320237C185592680 @default.
- W2048320237 hasConceptScore W2048320237C191732599 @default.
- W2048320237 hasConceptScore W2048320237C202751555 @default.
- W2048320237 hasConceptScore W2048320237C203014093 @default.
- W2048320237 hasConceptScore W2048320237C2776090121 @default.
- W2048320237 hasConceptScore W2048320237C2777991845 @default.
- W2048320237 hasConceptScore W2048320237C2778453870 @default.
- W2048320237 hasConceptScore W2048320237C2778690821 @default.
- W2048320237 hasConceptScore W2048320237C39347974 @default.
- W2048320237 hasConceptScore W2048320237C542903549 @default.
- W2048320237 hasConceptScore W2048320237C55493867 @default.
- W2048320237 hasConceptScore W2048320237C86803240 @default.
- W2048320237 hasConceptScore W2048320237C8891405 @default.
- W2048320237 hasIssue "1-3" @default.
- W2048320237 hasLocation W20483202371 @default.
- W2048320237 hasLocation W20483202372 @default.
- W2048320237 hasOpenAccess W2048320237 @default.
- W2048320237 hasPrimaryLocation W20483202371 @default.
- W2048320237 hasRelatedWork W1486068373 @default.
- W2048320237 hasRelatedWork W1533207120 @default.
- W2048320237 hasRelatedWork W1539910874 @default.
- W2048320237 hasRelatedWork W1654343738 @default.
- W2048320237 hasRelatedWork W1964547812 @default.
- W2048320237 hasRelatedWork W1989692667 @default.
- W2048320237 hasRelatedWork W2016307320 @default.
- W2048320237 hasRelatedWork W2084701318 @default.
- W2048320237 hasRelatedWork W2105735806 @default.
- W2048320237 hasRelatedWork W4313379353 @default.
- W2048320237 hasVolume "107" @default.
- W2048320237 isParatext "false" @default.
- W2048320237 isRetracted "false" @default.
- W2048320237 magId "2048320237" @default.
- W2048320237 workType "article" @default.