FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048320533> ?p ?o ?g. }

• W2048320533 endingPage "2743" @default.
• W2048320533 startingPage "2735" @default.
• W2048320533 abstract "Although diabetic cardiomyopathy is widely recognized, there are no specific treatments available. Altered myocardial substrate selection has emerged as a candidate mechanism behind the development of cardiac dysfunction in diabetes. As pyruvate dehydrogenase (PDH) activity appears central to the balance of substrate use, we aimed to investigate the relationship between PDH flux and myocardial function in a rodent model of type 2 diabetes and to explore whether or not increasing PDH flux, with dichloroacetate, would restore the balance of substrate use and improve cardiac function. All animals underwent in vivo hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy and echocardiography to assess cardiac PDH flux and function, respectively. Diabetic animals showed significantly higher blood glucose levels (10.8 ± 0.7 vs. 8.4 ± 0.5 mmol/L), lower PDH flux (0.005 ± 0.001 vs. 0.017 ± 0.002 s-1), and significantly impaired diastolic function (transmitral early diastolic peak velocity/early diastolic myocardial velocity ratio [E/E′] 12.2 ± 0.8 vs. 20 ± 2), which are in keeping with early diabetic cardiomyopathy. Twenty-eight days of treatment with dichloroacetate restored PDH flux to normal levels (0.018 ± 0.002 s-1), reversed diastolic dysfunction (E/E′ 14 ± 1), and normalized blood glucose levels (7.5 ± 0.7 mmol/L). The treatment of diabetes with dichloroacetate therefore restored the balance of myocardial substrate selection, reversed diastolic dysfunction, and normalized blood glucose levels. This suggests that PDH modulation could be a novel therapy for the treatment and/or prevention of diabetic cardiomyopathy." @default.
• W2048320533 created "2016-06-24" @default.
• W2048320533 creator A5003278789 @default.
• W2048320533 creator A5022593647 @default.
• W2048320533 creator A5024980731 @default.
• W2048320533 creator A5032891489 @default.
• W2048320533 creator A5033848873 @default.
• W2048320533 creator A5050716279 @default.
• W2048320533 creator A5062230304 @default.
• W2048320533 creator A5074019339 @default.
• W2048320533 creator A5082077038 @default.
• W2048320533 date "2015-03-20" @default.
• W2048320533 modified "2023-10-15" @default.
• W2048320533 title "Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study" @default.
• W2048320533 cites W1505433241 @default.
• W2048320533 cites W1681259700 @default.
• W2048320533 cites W177640679 @default.
• W2048320533 cites W1832257936 @default.
• W2048320533 cites W1885970184 @default.
• W2048320533 cites W1963542379 @default.
• W2048320533 cites W1968874936 @default.
• W2048320533 cites W1973860737 @default.
• W2048320533 cites W1982371325 @default.
• W2048320533 cites W1989101440 @default.
• W2048320533 cites W1989467867 @default.
• W2048320533 cites W1996820610 @default.
• W2048320533 cites W2002938395 @default.
• W2048320533 cites W2008875752 @default.
• W2048320533 cites W2020267609 @default.
• W2048320533 cites W2040456345 @default.
• W2048320533 cites W2054042932 @default.
• W2048320533 cites W2056133957 @default.
• W2048320533 cites W2059616389 @default.
• W2048320533 cites W2059900570 @default.
• W2048320533 cites W2066666306 @default.
• W2048320533 cites W2068327482 @default.
• W2048320533 cites W2070742041 @default.
• W2048320533 cites W2071518542 @default.
• W2048320533 cites W2071881770 @default.
• W2048320533 cites W2072080136 @default.
• W2048320533 cites W2079709085 @default.
• W2048320533 cites W2079717789 @default.
• W2048320533 cites W2081345866 @default.
• W2048320533 cites W2083163602 @default.
• W2048320533 cites W2083539959 @default.
• W2048320533 cites W2083993817 @default.
• W2048320533 cites W2086619682 @default.
• W2048320533 cites W2092026589 @default.
• W2048320533 cites W2093488803 @default.
• W2048320533 cites W2109820048 @default.
• W2048320533 cites W2118555195 @default.
• W2048320533 cites W2125005881 @default.
• W2048320533 cites W2127221234 @default.
• W2048320533 cites W2127331891 @default.
• W2048320533 cites W2144766505 @default.
• W2048320533 cites W2145397929 @default.
• W2048320533 cites W2153819921 @default.
• W2048320533 cites W2156137058 @default.
• W2048320533 cites W2159775950 @default.
• W2048320533 cites W4245224732 @default.
• W2048320533 cites W4246726366 @default.
• W2048320533 cites W4255437974 @default.
• W2048320533 cites W53646563 @default.
• W2048320533 cites W84564858 @default.
• W2048320533 doi "https://doi.org/10.2337/db14-1560" @default.
• W2048320533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4516266" @default.
• W2048320533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25795215" @default.
• W2048320533 hasPublicationYear "2015" @default.
• W2048320533 type Work @default.
• W2048320533 sameAs 2048320533 @default.
• W2048320533 citedByCount "89" @default.
• W2048320533 countsByYear W20483205332015 @default.
• W2048320533 countsByYear W20483205332016 @default.
• W2048320533 countsByYear W20483205332017 @default.
• W2048320533 countsByYear W20483205332018 @default.
• W2048320533 countsByYear W20483205332019 @default.
• W2048320533 countsByYear W20483205332020 @default.
• W2048320533 countsByYear W20483205332021 @default.
• W2048320533 countsByYear W20483205332022 @default.
• W2048320533 countsByYear W20483205332023 @default.
• W2048320533 crossrefType "journal-article" @default.
• W2048320533 hasAuthorship W2048320533A5003278789 @default.
• W2048320533 hasAuthorship W2048320533A5022593647 @default.
• W2048320533 hasAuthorship W2048320533A5024980731 @default.
• W2048320533 hasAuthorship W2048320533A5032891489 @default.
• W2048320533 hasAuthorship W2048320533A5033848873 @default.
• W2048320533 hasAuthorship W2048320533A5050716279 @default.
• W2048320533 hasAuthorship W2048320533A5062230304 @default.
• W2048320533 hasAuthorship W2048320533A5074019339 @default.
• W2048320533 hasAuthorship W2048320533A5082077038 @default.
• W2048320533 hasBestOaLocation W20483205331 @default.
• W2048320533 hasConcept C111566952 @default.
• W2048320533 hasConcept C126322002 @default.
• W2048320533 hasConcept C134018914 @default.
• W2048320533 hasConcept C164705383 @default.
• W2048320533 hasConcept C178790620 @default.
• W2048320533 hasConcept C181199279 @default.
• W2048320533 hasConcept C185592680 @default.

• next