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• W2048333904 endingPage "499" @default.
• W2048333904 startingPage "487" @default.
• W2048333904 abstract "This study investigates the effects of androgens, the antiandrogen flutamide and green tea catechins on glucose transport inhibition in human erythrocytes. These effects may relate to the antidiabetogenic effects of green tea. Testosterone, 4-androstene-3,17-dione, dehydroepiandrosterone (DHEA) and DHEA-3-acetate inhibit glucose exit from human erythrocytes with half-maximal inhibitions (Ki) of 39.2+/-8.9, 29.6+/-3.7, 48.1+/-10.2 and 4.8+/-0.98 microM, respectively. The antiandrogen flutamide competitively relieves these inhibitions and of phloretin. Dehydrotestosterone has no effect on glucose transport, indicating the differences between androgen interaction with GLUT1 and human androgen receptor (hAR). Green tea catechins also inhibit glucose exit from erythrocytes. Epicatechin 3-gallate (ECG) has a Ki ECG of 0.14+/-0.01 microM, and epigallocatechin 3-gallate (EGCG) has a Ki EGCG of 0.97+/-0.13 microM. Flutamide reverses these effects. Androgen-screening tests show that the green tea catechins do not act genomically. The high affinities of ECG and EGCG for GLUT1 indicate that this might be their physiological site of action. There are sequence homologies between GLUT1 and the ligand-binding domain (LBD) of hAR containing the amino-acid triads Arg 126, Thr 30 and Asn 288, and Arg 126, Thr 30 and Asn 29, with similar 3D topology to the polar groups binding 3-keto and 17-beta OH steroid groups in hAR LBD. These triads are appropriately sited for competitive inhibition of glucose import at the external opening of the hydrophilic pore traversing GLUT1." @default.
• W2048333904 created "2016-06-24" @default.
• W2048333904 creator A5004656353 @default.
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• W2048333904 date "2003-10-01" @default.
• W2048333904 modified "2023-10-14" @default.
• W2048333904 title "Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1" @default.
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• W2048333904 cites W1573981241 @default.
• W2048333904 cites W1967260913 @default.
• W2048333904 cites W1969303336 @default.
• W2048333904 cites W1971316445 @default.
• W2048333904 cites W1972464619 @default.
• W2048333904 cites W1973053346 @default.
• W2048333904 cites W1977015786 @default.
• W2048333904 cites W1982381000 @default.
• W2048333904 cites W1983879913 @default.
• W2048333904 cites W1986385116 @default.
• W2048333904 cites W1993777599 @default.
• W2048333904 cites W1996656661 @default.
• W2048333904 cites W1999108312 @default.
• W2048333904 cites W1999569654 @default.
• W2048333904 cites W2001990682 @default.
• W2048333904 cites W2007082739 @default.
• W2048333904 cites W2012307857 @default.
• W2048333904 cites W2015292449 @default.
• W2048333904 cites W2021949353 @default.
• W2048333904 cites W2028078929 @default.
• W2048333904 cites W2028816875 @default.
• W2048333904 cites W2034155024 @default.
• W2048333904 cites W2035119600 @default.
• W2048333904 cites W2037750278 @default.
• W2048333904 cites W2040585619 @default.
• W2048333904 cites W2042687133 @default.
• W2048333904 cites W2045483875 @default.
• W2048333904 cites W2045793599 @default.
• W2048333904 cites W2050216448 @default.
• W2048333904 cites W2052275076 @default.
• W2048333904 cites W2056202520 @default.
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• W2048333904 cites W2068072549 @default.
• W2048333904 cites W2068492818 @default.
• W2048333904 cites W2071931125 @default.
• W2048333904 cites W2074783201 @default.
• W2048333904 cites W2075866123 @default.
• W2048333904 cites W2078827423 @default.
• W2048333904 cites W2082886158 @default.
• W2048333904 cites W2085981499 @default.
• W2048333904 cites W2086833515 @default.
• W2048333904 cites W2091993475 @default.
• W2048333904 cites W2108241608 @default.
• W2048333904 cites W2117965089 @default.
• W2048333904 cites W2125207055 @default.
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• W2048333904 cites W2137889099 @default.
• W2048333904 cites W2142285790 @default.
• W2048333904 cites W2151922331 @default.
• W2048333904 cites W2152982678 @default.
• W2048333904 cites W2153663340 @default.
• W2048333904 cites W2160534562 @default.
• W2048333904 cites W2161306304 @default.
• W2048333904 cites W2161890108 @default.
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• W2048333904 doi "https://doi.org/10.1038/sj.bjp.0705460" @default.
• W2048333904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1574051" @default.
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