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- W2048347580 endingPage "e0122176" @default.
- W2048347580 startingPage "e0122176" @default.
- W2048347580 abstract "HIV-1 utilises -1 programmed ribosomal frameshifting to translate structural and enzymatic domains in a defined proportion required for replication. A slippery sequence, U UUU UUA, and a stem-loop are well-defined RNA features modulating -1 frameshifting in HIV-1. The GGG glycine codon immediately following the slippery sequence (the 'intercodon') contributes structurally to the start of the stem-loop but has no defined role in current models of the frameshift mechanism, as slippage is inferred to occur before the intercodon has reached the ribosomal decoding site. This GGG codon is highly conserved in natural isolates of HIV. When the natural intercodon was replaced with a stop codon two different decoding molecules-eRF1 protein or a cognate suppressor tRNA-were able to access and decode the intercodon prior to -1 frameshifting. This implies significant slippage occurs when the intercodon is in the (perhaps distorted) ribosomal A site. We accommodate the influence of the intercodon in a model of frame maintenance versus frameshifting in HIV-1." @default.
- W2048347580 created "2016-06-24" @default.
- W2048347580 creator A5001466717 @default.
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- W2048347580 date "2015-03-25" @default.
- W2048347580 modified "2023-09-27" @default.
- W2048347580 title "The Highly Conserved Codon following the Slippery Sequence Supports −1 Frameshift Efficiency at the HIV-1 Frameshift Site" @default.
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- W2048347580 doi "https://doi.org/10.1371/journal.pone.0122176" @default.
- W2048347580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4373837" @default.
- W2048347580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25807539" @default.
- W2048347580 hasPublicationYear "2015" @default.
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