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• W2048349218 startingPage "411" @default.
• W2048349218 abstract "During development of an extemporaneous suspension formulation for losartan potassium, previously unknown degradation products were observed in experimental suspensions prepared in a commercial cherry syrup vehicle. These degradates increased rapidly when analytical solutions prepared from that suspension were exposed to ambient light. The structures of the degradates were determined using a combination of preparative HPLC, LC/MS, (13)C and (1)H NMR (1D and 2D), and mechanistic chemistry. Each degradate results from destruction of the imidazole ring of losartan. Formation of the two major degradates required exposure to light (UV or visible) and the presence of oxygen. Experiments using Rose Bengal (a singlet oxygen photosensitizer) and 1,4-diazabicyclooctane (DABCO; a singlet oxygen quencher) established that the major photodegradates are formed via the intermediacy of singlet oxygen. The identity of the photosensitizer in the formulation was not unequivocally determined; however, the experiments implicated the artificial flavoring in fulfilling this role." @default.
• W2048349218 created "2016-06-24" @default.
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• W2048349218 date "2006-10-01" @default.
• W2048349218 modified "2023-10-16" @default.
• W2048349218 title "Photosensitized degradation of losartan potassium in an extemporaneous suspension formulation" @default.
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• W2048349218 doi "https://doi.org/10.1016/j.jpba.2006.04.030" @default.
• W2048349218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16787732" @default.
• W2048349218 hasPublicationYear "2006" @default.
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