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- W2048349737 abstract "Pretreatment with the nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), a competitive blocker of NO production, did not interfere with the development of sensitization to the behavioral activating effects of amphetamine (AMPH). On five pre-exposure sessions, at 3-day intervals, rats were given two i.p. injections, either 50 mg/kgL-NAME 30 min prior to 1.5 mg/kgD-AMPH sulfate, saline and AMPH,L-NAME and saline, or saline only.L-NAME reduced the levels of activity recorded during the pre-exposure session but had no effect on the degree of sensitization shown to a challenge injection of 0.5 mg/kg AMPH given 10 days later. A separate study using in vivo microdialysis showed that pretreatment withL-NAME did not alter AMPH-stimulated dopamine release in nucleus accumbens." @default.
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- W2048349737 date "1994-03-01" @default.
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- W2048349737 title "Inhibition of nitric oxide synthase does not block the development of sensitization to the behavioral activating effects of amphetamine" @default.
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- W2048349737 doi "https://doi.org/10.1016/0006-8993(94)91827-9" @default.
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