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- W2048349743 endingPage "950" @default.
- W2048349743 startingPage "931" @default.
- W2048349743 abstract "Recent studies have demonstrated that human islet allograft transplantation can be a successful therapeutic option in the treatment of patients with Type I diabetes. However, this impressive recent advance is accompanied by a very important constraint. There is a critical paucity of pancreatic islets or pancreatic beta cells for islet transplantation to become a large-scale therapeutic option in patients with diabetes. This has prompted many laboratories around the world to invigorate their efforts in finding ways for increasing the availability of beta cells or beta cell surrogates that potentially could be transplanted into patients with diabetes. The number of studies analyzing the mechanisms that govern beta cell proliferation and growth in physiological and pathological conditions has increased exponentially during the last decade. These studies exploring the role of growth factors, intracellular signaling molecules and cell cycle regulators constitute the substrate for future strategies aimed at expanding human beta cells in vitro and/or in vivo after transplantation. In this review, we describe the current knowledge on the effects of several beta cell growth factors that have been shown to increase beta cell proliferation and expand beta cell mass in vitro and/or in vivo and that they could be potentially deployed in an effort to increase the number of patients transplanted with islets. Furthermore, we also analyze in this review recent studies deciphering the relevance of these specific islet growth factors as physiological and pathophysiological regulators of beta cell proliferation and islet growth." @default.
- W2048349743 created "2016-06-24" @default.
- W2048349743 creator A5006140692 @default.
- W2048349743 creator A5006892022 @default.
- W2048349743 creator A5009544575 @default.
- W2048349743 creator A5027526622 @default.
- W2048349743 creator A5029008383 @default.
- W2048349743 creator A5034196201 @default.
- W2048349743 date "2006-05-01" @default.
- W2048349743 modified "2023-10-18" @default.
- W2048349743 title "Growth factors and beta cell replication" @default.
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