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• W2048349744 abstract "The rectal absorption-enhancing abilities of several medium-chain alkyl saccharides, i.e., n -octyl β-glycopyranoside (OG), n -decyl β-glucopyranoside (DG), n -decyl β-maltopyranoside (DM), n -dodecyl β-glucopyranoside (LG) and n -dodecyl β-maltopyranoside (LM), were evaluated by in vivo rat studies. Carboxyfluorescein (CF) was used a poorly absorbable model compound in the absorption experiments. The absorption of CF was enhanced about 3–10-fold vs the control by the addition of these compounds at their most appropriate doses; the order of efficacy was: LM > DM ≑ DG > OG > LG. LM possesses excellent properties for use as an absorption enhancer and is superior to the known absorption enhancers caprate and/or laurate. The enhancement effect of LM is reversible and readily restored to the normal level by washing out; LM is also effective in increasing the absorption of high molecular weight compounds such as FITC-dextrans, and no apparent histological change was observed in the rectal mucosa on treatment with LM. The absorption enhancing effect of the alkyl saccharides was reduced by the combined use of HCO-60 and LM whereas the effect was increased on co-administration of HCO-60 and LG. The lack of effect of the addition of Ca 2+ and Mg 2+ suggests that chelation can be ruled out as a possible mechanism for the absorption-enhancing action of LM." @default.
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• W2048349744 date "1992-02-01" @default.
• W2048349744 modified "2023-09-26" @default.
• W2048349744 title "Assessment of enhancing ability of medium-chain alkyl saccharides as new absorption enhancers in rat rectum" @default.
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• W2048349744 doi "https://doi.org/10.1016/0378-5173(92)90107-d" @default.
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