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• W2048360665 abstract "No AccessJournal of UrologyChordee/Hypospadias/Penile Reconstruction1 Sep 1998ANATOMICAL STUDIES OF HYPOSPADIAS LAURENCE S. BASKIN, ALI EROL, YING WU LI, and GERALD R. CUNHA LAURENCE S. BASKINLAURENCE S. BASKIN More articles by this author , ALI EROLALI EROL More articles by this author , YING WU LIYING WU LI More articles by this author , and GERALD R. CUNHAGERALD R. CUNHA More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62711-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Hypospadias is the most common congenital anomaly affecting the penis. Successful repair depends on an accurate understanding of anatomy. We compared the anatomy of hypospadiac and normal fetal penises. Materials and Methods: A fetal penis at 33 weeks of gestation with distal shaft hypospadias was serially sectioned and compared to 10 normal human fetal specimens at 8 to 32 weeks of gestation. Immunohistochemical localization was performed with S-100 protein and protein gene product 9.5 to localize neurons. Blood vessels were localized by the presence of red corpuscles, and immunohistochemical staining with von Willebrand's factor and factor VIII. Three-dimensional computer reconstructions of the nerves, corporeal bodies, tunica and urethra of the hypospadiac and normal fetal penises were compared. Results: Except at the region of the abnormal urethral spongiosum and glans, the hypospadiac and normal penises showed no difference in neuronal innervation, corpora cavernosa and tunica albuginea architecture and blood supply. The nerves started proximally as 2 well defined bundles under the pubic rami superior and slightly lateral to the urethra. As the 2 crural bodies converged into the corpora cavernosa, the nerves diverged, spreading around the cavernous bodies up to the junction with the urethral spongiosum without remaining at the 11 and 1 o'clock positions. Along the entire shaft of the penis there were no neuronal structures at the 12 o'clock position. The most striking difference was in vascularity. In the hypospadiac penis factor VIII immunostaining revealed huge endothelial lined vascular channels filled with red blood cells. In contrast, the normal penis had well defined small capillaries around the urethra that fanned out into the glans. Vascularity was also extensive under the urethral plate. Nerve distribution in the abnormal glans was also less extensive than in the normal penis. Conclusions: Increased knowledge of normal and hypospadiac penile anatomy with respect to the nerves, corporeal bodies, glans and vascularity is useful for the strategic design of penile reconstructive procedures. 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An Experimental Animal StudyJournal of Urology, VOL. 186, NO. 4S, (1625-1630), Online publication date: 1-Oct-2011.Lalla M, Gregersen H, Olsen L and Jørgensen T (2010) In Vivo Biomechanical Assessment of Anterior Rabbit Urethra After Repair of Surgically Created HypospadiasJournal of Urology, VOL. 184, NO. 2, (675-682), Online publication date: 1-Aug-2010.Snodgrass W and Prieto J (2009) Straightening Ventral Curvature While Preserving the Urethral Plate in Proximal Hypospadias RepairJournal of Urology, VOL. 182, NO. 4S, (1720-1725), Online publication date: 1-Oct-2009.Baskin L (2008) Editorial CommentJournal of Urology, VOL. 180, NO. 4S, (1747-1747), Online publication date: 1-Oct-2008.Poppas D, Hochsztein A, Baergen R, Loyd E, Chen J and Felsen D (2007) Nerve Sparing Ventral Clitoroplasty Preserves Dorsal Nerves in Congenital Adrenal HyperplasiaJournal of Urology, VOL. 178, NO. 4S, (1802-1806), Online publication date: 1-Oct-2007.Snodgrass W (2007) A Farewell to ChordeeJournal of Urology, VOL. 178, NO. 3, (753-754), Online publication date: 1-Sep-2007.Baskin L (2018) Editorial commentJournal of Urology, VOL. 175, NO. 2, (702-703), Online publication date: 1-Feb-2006.Baskin L, Yucel S, Cunha G, Glickman S and Place N (2018) A Neuroanatomical Comparison of Humans and Spotted Hyena, a Natural Animal Model for Common Urogenital Sinus: Clinical Reflections on Feminizing GenitoplastyJournal of Urology, VOL. 175, NO. 1, (276-283), Online publication date: 1-Jan-2006.XU J, LI S, LI Y, LI Q, LIU L and WANG Y (2018) LENGTHENING URETHRAL PLATE WITH INNER PREPUTIAL SKIN GRAFTS: A MODIFICATION OF THE ONLAY TECHNIQUEJournal of Urology, VOL. 173, NO. 1, (202-203), Online publication date: 1-Jan-2005.YUCEL S, GUNTEKIN E, KUKUL E, KARAGUZEL G, CIFTCIOGLU A, MELIKOGLU M and BAYKARA M (2018) COMPARISON OF HYPOSPADIAC AND NORMAL PREPUTIAL VASCULAR ANATOMYJournal of Urology, VOL. 172, NO. 5, (1973-1976), Online publication date: 1-Nov-2004.YOSEF Y, BINYAMINI J, MATZKIN H and BEN-CHAIM J (2018) MIDLINE DORSAL PLICATION TECHNIQUE FOR PENILE CURVATURE REPAIRJournal of Urology, VOL. 172, NO. 4 Part 1, (1368-1369), Online publication date: 1-Oct-2004.UDA A, KOJIMA Y, HAYASHI Y, MIZUNO K, ASAI N and KOHRI K (2018) Morphological Features of External Genitalia in Hypospadiac Rat Model: 3-Dimensional AnalysisJournal of Urology, VOL. 171, NO. 3, (1362-1366), Online publication date: 1-Mar-2004.Kropp B, Cheng E, Pope J, Brock J, Koyle M, Furness P, Weigel N, Keck R and Kropp K (2018) Use of Small Intestinal Submucosa for Corporal Body Grafting in Cases of Severe Penile CurvatureJournal of Urology, VOL. 168, NO. 4 Part 2, (1742-1745), Online publication date: 1-Oct-2002.DAREWICZ B, KUDELSKI J, SZYNAKA B, NOWAK H and DAREWICZ J (2018) ULTRASTRUCTURE OF THE TUNICA ALBUGINEA IN CONGENITAL PENILE CURVATUREJournal of Urology, VOL. 166, NO. 5, (1766-1768), Online publication date: 1-Nov-2001.LOPES J, SCHNED A, ELLSWORTH P and CENDRON M (2018) HISTOLOGICAL ANALYSIS OF URETHRAL HEALING AFTER TUBULARIZED INCISED PLATE URETHROPLASTYJournal of Urology, VOL. 166, NO. 3, (1014-1017), Online publication date: 1-Sep-2001.AKMAN Y, LIU W, LI Y and BASKIN L (2018) PENILE ANATOMY UNDER THE PUBIC ARCH: RECONSTRUCTIVE IMPLICATIONSJournal of Urology, VOL. 166, NO. 1, (225-230), Online publication date: 1-Jul-2001.BORER J, BAUER S, PETERS C, DIAMOND D, ATALA A, CILENTO B and RETIK A (2018) TUBULARIZED INCISED PLATE URETHROPLASTY:: EXPANDED USE IN PRIMARY AND REPEAT SURGERY FOR HYPOSPADIASJournal of Urology, VOL. 165, NO. 2, (581-585), Online publication date: 1-Feb-2001.BLEUSTEIN C, ESPOSITO M, SOSLOW R, FELSEN D and POPPAS D (2018) MECHANISM OF HEALING FOLLOWING THE SNODGRASS REPAIRJournal of Urology, VOL. 165, NO. 1, (277-279), Online publication date: 1-Jan-2001.KOGAN B (2018) INTRAOPERATIVE PHARMACOLOGICAL ERECTION AS AN AID TO PEDIATRIC HYPOSPADIAS REPAIRJournal of Urology, VOL. 164, NO. 6, (2058-2061), Online publication date: 1-Dec-2000.KURZROCK E, JEGATHEESAN P, CUNHA G and BASKIN L (2018) URETHRAL DEVELOPMENT IN THE FETAL RABBIT AND INDUCTION OF HYPOSPADIAS: A MODEL FOR HUMAN DEVELOPMENTJournal of Urology, VOL. 164, NO. 5, (1786-1792), Online publication date: 1-Nov-2000.SNODGRASS W, PATTERSON K, PLAIRE J, GRADY R and MITCHELL M (2018) HISTOLOGY OF THE URETHRAL PLATE: IMPLICATIONS FOR HYPOSPADIAS REPAIRJournal of Urology, VOL. 164, NO. 3 Part 2, (988-990), Online publication date: 1-Sep-2000.BASKIN L, EROL A, LI Y and LIU W (2018) ANATOMY OF THE NEUROVASCULAR BUNDLE: IS SAFE MOBILIZATION POSSIBLE?Journal of Urology, VOL. 164, NO. 3 Part 2, (977-980), Online publication date: 1-Sep-2000.KOLON T and GONZALES E (2018) THE DORSAL INLAY GRAFT FOR HYPOSPADIAS REPAIRJournal of Urology, VOL. 163, NO. 6, (1941-1943), Online publication date: 1-Jun-2000.Baskin L (2018) HYPOSPADIAS AND URETHRAL DEVELOPMENTJournal of Urology, VOL. 163, NO. 3, (951-956), Online publication date: 1-Mar-2000.SNODGRASS W (2018) DOES TUBULARIZED INCISED PLATE HYPOSPADIAS REPAIR CREATE NEOURETHRAL STRICTURES?Journal of Urology, VOL. 162, NO. 3 Part 2, (1159-1161), Online publication date: 1-Sep-1999.DECTER R (2018) CHORDEE CORRECTION BY CORPORAL ROTATION: THE SPLIT AND ROLL TECHNIQUEJournal of Urology, VOL. 162, NO. 3 Part 2, (1152-1154), Online publication date: 1-Sep-1999.BASKIN L, EROL A, LI Y, LIU W, KURZROCK E and CUNHA G (2018) ANATOMICAL STUDIES OF THE HUMAN CLITORISJournal of Urology, VOL. 162, NO. 3 Part 2, (1015-1020), Online publication date: 1-Sep-1999.BASKIN L (2018) FETAL GENITAL ANATOMY RECONSTRUCTIVE IMPLICATIONSJournal of Urology, VOL. 162, NO. 2, (527-529), Online publication date: 1-Aug-1999. Volume 160Issue 3 Part 2September 1998Page: 1108-1115 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information LAURENCE S. BASKIN More articles by this author ALI EROL More articles by this author YING WU LI More articles by this author GERALD R. CUNHA More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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