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• W2048360669 startingPage "81" @default.
• W2048360669 abstract "The stability of indomethacin (IM) compounded with SiO(2) either by co-grinding or by melt-quenching was examined by recrystallization kinetics under the conditions 30 degrees C and 11% relative humidity. A decrease of the recrystallization rate with and without an appreciable induction period was observed in both compounds. Higher stability of amorphous IM compounded with SiO(2) was attained by prolonged co-grinding than by melt-quenching. This was explained by the stronger chemical interaction at the interface between IM and SiO(2) by co-grinding, as revealed by (29)Si and (13)C solid state NMR. Incomplete co-grinding with the rest of the crystalline state, however, made the amorphous state appreciably unstable, since the remaining crystallites serve as seeds for recrystallization." @default.
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• W2048360669 date "2001-09-01" @default.
• W2048360669 modified "2023-09-29" @default.
• W2048360669 title "Stability of amorphous indomethacin compounded with silica" @default.
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• W2048360669 doi "https://doi.org/10.1016/s0378-5173(01)00776-1" @default.
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