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- W2048362978 abstract "The effects of 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid (DIDS), an inhibitor of the Cl − HCO 3 − exchanger, and amiloride, an inhibitor of the Na + H + exchanger, on gastric acid secretion under basal conditions and after stimulation with bethanechol or dibutyryl cyclic AMP were studied in rat gastric mucosa sheet preparation. DIDS inhibited bethanechol-induced acid secretion in a dose-dependent manner, but amiloride had no effect. The stimulation of acid secretion by dibutyryl cyclic AMP plus 3-isobutyl-1-methylxanthine was also inhibited by DIDS, but not by amiloride. DIDS did not reduce basal acid secretion, and neither did amiloride. These results suggest that the Cl − HCO 3 − exchanger in the basolateral membrane of the parietal cell plays an important role in stimulated gastric acid secretion and that the Na + H + exchanger is less important. In addition, these data show that DIDS inhibits stimulated gastric acid secretion irrespective of the secretagogue, but not basal gastric acid secretion." @default.
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- W2048362978 date "1992-12-01" @default.
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- W2048362978 title "Effects of drugs acting on Cl−HCO3− and Na+H+ exchangers on acid secretion in the rat gastric mucosa sheet preparation" @default.
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- W2048362978 doi "https://doi.org/10.1016/0014-2999(92)90280-h" @default.
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