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- W2048364464 abstract "Many autoimmune diseases are associated with specific alleles of the major histocompatibility complex (MHC), but how a particular MHC allele contributes to a particular disease is often not known. The MHC class II allele HLA-DQ8 has been linked to celiac disease, an autoimmune disease driven by T cell responses against dietary gluten, as occurs in wheat, for example. In contrast to other MHC alleles, HLA-DQ8 lacks an aspartic acid residue in its peptide-binding pocket and thus preferentially binds to peptides and T cell receptors (TCRs) that carry a negative charge. In celiac disease, negatively charged gluten-derived peptides are generated by tissue transglutaminase (which converts glutamine to glutamic acid); however, how HLA-DQ8 contributes to disease is not clear because transglutaminase requires inflammation for its activation." @default.
- W2048364464 created "2016-06-24" @default.
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- W2048364464 date "2009-01-02" @default.
- W2048364464 modified "2023-09-26" @default.
- W2048364464 title "IMMUNOLOGY: Finding Negatives Wherever" @default.
- W2048364464 doi "https://doi.org/10.1126/science.323.5910.16c" @default.
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