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• W2048366953 abstract "Release of macromolecular drug from calcium–alginate gel beads was investigated. Fluorescein isothiocyanate-labeled dextrans with molecular weight ranging from 9400 to 145 000 were used as a model macromolecular drug. Dextran release was observed to be molecular weight-dependent, with the release pattern changing from pseudo first-order for dextran with 9400 molecular weight to sigmoidal for dextran with molecular weight of 145 000. Release of a lower molecular weight dextran is mainly governed by the drug diffusion through the calcium–alginate gel matrix. With increasing dextran molecular weights, dextran release was strongly influenced by the dissolution of alginate matrix through the exchange of Ca2+ ions which act as a cross-linker. Rapid and complete release was achieved for dextran with 145 000 molecular weight in a “burst” fashion showing a initial lag time. Minimal dextran release was observed in pseudo-gastric fluid at pH 1.2, while rapid dextran release within a narrow time range was achieved in simulated intestinal fluid at pH 6.8. These results strongly suggest that calcium–alginate gel is a useful vehicle for pulsatile release of macromolecular drugs in oral drug delivery." @default.
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• W2048366953 date "1999-03-01" @default.
• W2048366953 modified "2023-10-16" @default.
• W2048366953 title "Effect of Ca2+-alginate gel dissolution on release of dextran with different molecular weights" @default.
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• W2048366953 doi "https://doi.org/10.1016/s0168-3659(98)00141-2" @default.
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