Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048372452> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2048372452 endingPage "e163" @default.
- W2048372452 startingPage "e159" @default.
- W2048372452 abstract "OBJECTIVES. Our goal was to determine long-term efficacy and safety of B-cell–depletion therapy for children with autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus. PATIENTS AND METHODS. A retrospective, single-center cohort study was conducted including all patients with pediatric systemic lupus erythematosus who were diagnosed with autoimmune thrombocytopenia and/or autoimmune hemolytic anemia and treated with rituximab. Treatment efficacy and safety parameters were monitored and recorded. RESULTS. Nine patients with pediatric systemic lupus erythematosus were included in the study: 5 had autoimmune thrombocytopenia, 3 had autoimmune hemolytic anemia, and 1 had both. There were 5 female and 4 male patients; median age at diagnosis of pediatric systemic lupus erythematosus was 14 years (range: 8–16 years); and median pediatric systemic lupus erythematosus disease duration to time of rituximab treatment was 6 months (range: 2–30 months). Complete response was achieved in all 6 children with autoimmune thrombocytopenia (median time to complete response: 2 weeks [range: 1–12 weeks]). Two patients' conditions flared at 48 and 68 weeks, respectively, and were re-treated. The remaining 4 patients continued to be in remission at 24, 32, 36, and 88 weeks, respectively. All 4 children with autoimmune hemolytic anemia achieved complete response at a median time of 4 weeks (range: 4–32 weeks). All patients remained in complete response at 24, 44, 84, and 100 weeks of follow-up. Complete B-cell depletion was seen in all children after rituximab treatment. No serious infections occurred, but 1 patient had an infusion reaction. CONCLUSIONS. Preliminary evidence suggests that B-cell–depletion therapy with rituximab is an efficacious and safe treatment for autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus. Despite the prolonged effect on B-cell numbers and function, no serious infections were observed." @default.
- W2048372452 created "2016-06-24" @default.
- W2048372452 creator A5001363784 @default.
- W2048372452 creator A5038335245 @default.
- W2048372452 creator A5047679905 @default.
- W2048372452 creator A5068482103 @default.
- W2048372452 date "2009-01-01" @default.
- W2048372452 modified "2023-10-14" @default.
- W2048372452 title "B-Cell Depletion for Autoimmune Thrombocytopenia and Autoimmune Hemolytic Anemia in Pediatric Systemic Lupus Erythematosus" @default.
- W2048372452 cites W1963970819 @default.
- W2048372452 cites W1978620649 @default.
- W2048372452 cites W1982626297 @default.
- W2048372452 cites W2045508048 @default.
- W2048372452 cites W2052970048 @default.
- W2048372452 cites W2072812077 @default.
- W2048372452 cites W2077409993 @default.
- W2048372452 cites W2090592605 @default.
- W2048372452 cites W2108787411 @default.
- W2048372452 cites W2109553594 @default.
- W2048372452 cites W2130945067 @default.
- W2048372452 cites W2133880339 @default.
- W2048372452 cites W2134547857 @default.
- W2048372452 doi "https://doi.org/10.1542/peds.2008-2361" @default.
- W2048372452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19074962" @default.
- W2048372452 hasPublicationYear "2009" @default.
- W2048372452 type Work @default.
- W2048372452 sameAs 2048372452 @default.
- W2048372452 citedByCount "55" @default.
- W2048372452 countsByYear W20483724522012 @default.
- W2048372452 countsByYear W20483724522013 @default.
- W2048372452 countsByYear W20483724522014 @default.
- W2048372452 countsByYear W20483724522015 @default.
- W2048372452 countsByYear W20483724522016 @default.
- W2048372452 countsByYear W20483724522017 @default.
- W2048372452 countsByYear W20483724522018 @default.
- W2048372452 countsByYear W20483724522019 @default.
- W2048372452 countsByYear W20483724522021 @default.
- W2048372452 countsByYear W20483724522022 @default.
- W2048372452 crossrefType "journal-article" @default.
- W2048372452 hasAuthorship W2048372452A5001363784 @default.
- W2048372452 hasAuthorship W2048372452A5038335245 @default.
- W2048372452 hasAuthorship W2048372452A5047679905 @default.
- W2048372452 hasAuthorship W2048372452A5068482103 @default.
- W2048372452 hasConcept C126322002 @default.
- W2048372452 hasConcept C159654299 @default.
- W2048372452 hasConcept C167135981 @default.
- W2048372452 hasConcept C203014093 @default.
- W2048372452 hasConcept C2775915377 @default.
- W2048372452 hasConcept C2776175824 @default.
- W2048372452 hasConcept C2777385706 @default.
- W2048372452 hasConcept C2778248108 @default.
- W2048372452 hasConcept C2779075594 @default.
- W2048372452 hasConcept C2780653079 @default.
- W2048372452 hasConcept C2910196583 @default.
- W2048372452 hasConcept C71924100 @default.
- W2048372452 hasConceptScore W2048372452C126322002 @default.
- W2048372452 hasConceptScore W2048372452C159654299 @default.
- W2048372452 hasConceptScore W2048372452C167135981 @default.
- W2048372452 hasConceptScore W2048372452C203014093 @default.
- W2048372452 hasConceptScore W2048372452C2775915377 @default.
- W2048372452 hasConceptScore W2048372452C2776175824 @default.
- W2048372452 hasConceptScore W2048372452C2777385706 @default.
- W2048372452 hasConceptScore W2048372452C2778248108 @default.
- W2048372452 hasConceptScore W2048372452C2779075594 @default.
- W2048372452 hasConceptScore W2048372452C2780653079 @default.
- W2048372452 hasConceptScore W2048372452C2910196583 @default.
- W2048372452 hasConceptScore W2048372452C71924100 @default.
- W2048372452 hasIssue "1" @default.
- W2048372452 hasLocation W20483724521 @default.
- W2048372452 hasLocation W20483724522 @default.
- W2048372452 hasOpenAccess W2048372452 @default.
- W2048372452 hasPrimaryLocation W20483724521 @default.
- W2048372452 hasRelatedWork W1966252951 @default.
- W2048372452 hasRelatedWork W2031169969 @default.
- W2048372452 hasRelatedWork W2124867438 @default.
- W2048372452 hasRelatedWork W217291921 @default.
- W2048372452 hasRelatedWork W2349106291 @default.
- W2048372452 hasRelatedWork W2413518911 @default.
- W2048372452 hasRelatedWork W2415583261 @default.
- W2048372452 hasRelatedWork W4221109305 @default.
- W2048372452 hasRelatedWork W54895041 @default.
- W2048372452 hasRelatedWork W70941328 @default.
- W2048372452 hasVolume "123" @default.
- W2048372452 isParatext "false" @default.
- W2048372452 isRetracted "false" @default.
- W2048372452 magId "2048372452" @default.
- W2048372452 workType "article" @default.