FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048376791> ?p ?o ?g. }

• W2048376791 endingPage "2399" @default.
• W2048376791 startingPage "2391" @default.
• W2048376791 abstract "Ewing sarcoma is a malignant bone cancer that primarily occurs in children and adolescents. Eighty-five percent of Ewing sarcoma is characterized by the presence of the aberrant chimeric EWS/FLI1 fusion gene. Previously, we demonstrated that an interaction between EWS/FLI1 and wild-type EWS led to the inhibition of EWS activity and mitotic dysfunction. Although defective mitosis is considered to be a critical step in cancer initiation, it is unknown how interference with EWS contributes to Ewing sarcoma formation. Here, we demonstrate that EWS/FLI1- and EWS-knockdown cells display a high incidence of defects in the midzone, a midline structure located between segregating chromatids during anaphase. Defects in the midzone can lead to the failure of cytokinesis and can result in the induction of aneuploidy. The similarity among the phenotypes of EWS/FLI1- and EWS siRNA-transfected HeLa cells points to the inhibition of EWS as the key mechanism for the induction of midzone defects. Supporting this observation, the ectopic expression of EWS rescues the high incidence of midzone defects observed in Ewing sarcoma A673 cells. We discovered that EWS interacts with Aurora B kinase, and that EWS is also required for recruiting Aurora B to the midzone. A domain analysis revealed that the R565 in the RGG3 domain of EWS is essential for both Aurora B interaction and the recruitment of Aurora B to the midzone. Here, we propose that the impairment of EWS-dependent midzone formation via the recruitment of Aurora B is a potential mechanism of Ewing sarcoma development." @default.
• W2048376791 created "2016-06-24" @default.
• W2048376791 creator A5005727339 @default.
• W2048376791 creator A5007021932 @default.
• W2048376791 creator A5023996560 @default.
• W2048376791 creator A5043456907 @default.
• W2048376791 creator A5047848336 @default.
• W2048376791 creator A5071339101 @default.
• W2048376791 creator A5091426655 @default.
• W2048376791 date "2014-06-19" @default.
• W2048376791 modified "2023-10-18" @default.
• W2048376791 title "Ewing sarcoma EWS protein regulates midzone formation by recruiting Aurora B kinase to the midzone" @default.
• W2048376791 cites W1966521684 @default.
• W2048376791 cites W1971930060 @default.
• W2048376791 cites W1975078069 @default.
• W2048376791 cites W1979425243 @default.
• W2048376791 cites W1981188079 @default.
• W2048376791 cites W1992232630 @default.
• W2048376791 cites W1995745247 @default.
• W2048376791 cites W1996375162 @default.
• W2048376791 cites W1996965392 @default.
• W2048376791 cites W2000061217 @default.
• W2048376791 cites W2004212955 @default.
• W2048376791 cites W2007438323 @default.
• W2048376791 cites W2008510359 @default.
• W2048376791 cites W2009876130 @default.
• W2048376791 cites W2017046792 @default.
• W2048376791 cites W2018799668 @default.
• W2048376791 cites W2020168080 @default.
• W2048376791 cites W2025527937 @default.
• W2048376791 cites W2034729360 @default.
• W2048376791 cites W2045451529 @default.
• W2048376791 cites W2050723856 @default.
• W2048376791 cites W2051833743 @default.
• W2048376791 cites W2058759427 @default.
• W2048376791 cites W2062214822 @default.
• W2048376791 cites W2065552057 @default.
• W2048376791 cites W2069351898 @default.
• W2048376791 cites W2072023036 @default.
• W2048376791 cites W2076107852 @default.
• W2048376791 cites W2081188533 @default.
• W2048376791 cites W2095186653 @default.
• W2048376791 cites W2096113686 @default.
• W2048376791 cites W2102770794 @default.
• W2048376791 cites W2112539355 @default.
• W2048376791 cites W2125247503 @default.
• W2048376791 cites W2138736258 @default.
• W2048376791 cites W2146926661 @default.
• W2048376791 cites W2147440283 @default.
• W2048376791 cites W2155453571 @default.
• W2048376791 cites W2160087268 @default.
• W2048376791 cites W2164937682 @default.
• W2048376791 cites W2165691575 @default.
• W2048376791 cites W2170213020 @default.
• W2048376791 cites W2317783677 @default.
• W2048376791 cites W83261268 @default.
• W2048376791 doi "https://doi.org/10.4161/cc.29337" @default.
• W2048376791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4128884" @default.
• W2048376791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25483190" @default.
• W2048376791 hasPublicationYear "2014" @default.
• W2048376791 type Work @default.
• W2048376791 sameAs 2048376791 @default.
• W2048376791 citedByCount "18" @default.
• W2048376791 countsByYear W20483767912015 @default.
• W2048376791 countsByYear W20483767912016 @default.
• W2048376791 countsByYear W20483767912017 @default.
• W2048376791 countsByYear W20483767912018 @default.
• W2048376791 countsByYear W20483767912019 @default.
• W2048376791 countsByYear W20483767912020 @default.
• W2048376791 countsByYear W20483767912021 @default.
• W2048376791 countsByYear W20483767912023 @default.
• W2048376791 crossrefType "journal-article" @default.
• W2048376791 hasAuthorship W2048376791A5005727339 @default.
• W2048376791 hasAuthorship W2048376791A5007021932 @default.
• W2048376791 hasAuthorship W2048376791A5023996560 @default.
• W2048376791 hasAuthorship W2048376791A5043456907 @default.
• W2048376791 hasAuthorship W2048376791A5047848336 @default.
• W2048376791 hasAuthorship W2048376791A5071339101 @default.
• W2048376791 hasAuthorship W2048376791A5091426655 @default.
• W2048376791 hasBestOaLocation W20483767911 @default.
• W2048376791 hasConcept C104317684 @default.
• W2048376791 hasConcept C121608353 @default.
• W2048376791 hasConcept C141937037 @default.
• W2048376791 hasConcept C142724271 @default.
• W2048376791 hasConcept C1491633281 @default.
• W2048376791 hasConcept C164265269 @default.
• W2048376791 hasConcept C173396325 @default.
• W2048376791 hasConcept C20552341 @default.
• W2048376791 hasConcept C2777937962 @default.
• W2048376791 hasConcept C2778256501 @default.
• W2048376791 hasConcept C29537977 @default.
• W2048376791 hasConcept C45472230 @default.
• W2048376791 hasConcept C502942594 @default.
• W2048376791 hasConcept C53420372 @default.
• W2048376791 hasConcept C54355233 @default.
• W2048376791 hasConcept C71924100 @default.
• W2048376791 hasConcept C85813293 @default.
• W2048376791 hasConcept C86339819 @default.

• next