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• W2048389969 abstract "Induction of the proto-oncogene c-fos is often considered to be a marker of increased neuronal activity. We have used in situ hybridization to study the pattern of c-fos expression in limbic structures following kainic acid-induced seizures during the postnatal period in the rat. Prior to postnatal day 13 (P13), seizure activity did not result in c-fos induction in any limbic structure. Between P13 and P25, a gradual increase in c-fos expression was observed in hippocampus and cortical structures. These results were corroborated by nuclear run-off transcription assay. Thus, alterations in c-fos transcription that may facilitate stimulus-transcription coupling occur during postnatal development. The possible relationship between the postnatal maturation of c-fos expression and the increase in susceptibility of specific neuronal populations to seizure-induced cell damage is discussed." @default.
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• W2048389969 date "1992-02-01" @default.
• W2048389969 modified "2023-10-07" @default.
• W2048389969 title "Absence of c-fos induction in neonatal rat brain after seizures" @default.
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• W2048389969 doi "https://doi.org/10.1016/0304-3940(92)90640-s" @default.
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