Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048390434> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2048390434 endingPage "250" @default.
- W2048390434 startingPage "245" @default.
- W2048390434 abstract "To study the penetration of tobramycin in lung tissue evaluated as the concentration in epithelial lining fluid and to characterize the time course of the drug in the treatment of patients with pneumonia.The subjects were 16 patients with pneumonia and taking tobramycin who had clinical indications for bronchoscopy. Bronchoscopy with bronchoalveolar lavage of the pneumonic area was performed once on each patient 1/2%, 2, 4, or 8 hours after the previous tobramycin dose. Urea was used as an endogenous marker for quantification of epithelial lining fluid obtained at bronchoalveolar lavage. Tobramycin concentrations in serum were measured for all patients at the aforementioned 4 time points. Tobramycin concentration was determined by means of fluorescent polarization immunoassay modified for bronchoalveolar samples.Levels of tobramycin in the fluid of the epithelial lining were 2.33+/-0.5 at 1/2 hour, 1.67+/-0.6 at 2 hours, 1.62+/-1.19 at 4 hours, and 0.77+/-0.38 microg/mL at 8 hours. The ratio of epithelial lining fluid to serum concentration of tobramycin was 0.30+/-0.03 at 1/2 hour, 0.42+/-0.16 at 2 hours, 0.64+/-0.37 at 4 hours, and 1.53+/-0.76 at 8 hours. The ratio at peak serum time was similar to that reported for tobramycin and netilmicin.High peak serum concentrations of tobramycin are necessary to obtain microbiologically active concentrations at the alveolar level. The fluid of the epithelial lining constitutes a deep compartment for aminoglycosides. The disappearance of tobramycin was slower than at the serum level." @default.
- W2048390434 created "2016-06-24" @default.
- W2048390434 creator A5009490514 @default.
- W2048390434 creator A5031942079 @default.
- W2048390434 creator A5041984607 @default.
- W2048390434 creator A5069496269 @default.
- W2048390434 date "1999-03-01" @default.
- W2048390434 modified "2023-10-14" @default.
- W2048390434 title "Tobramycin penetration into epithelial lining fluid of patients with pneumonia" @default.
- W2048390434 doi "https://doi.org/10.1016/s0009-9236(99)70103-7" @default.
- W2048390434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10096256" @default.
- W2048390434 hasPublicationYear "1999" @default.
- W2048390434 type Work @default.
- W2048390434 sameAs 2048390434 @default.
- W2048390434 citedByCount "72" @default.
- W2048390434 countsByYear W20483904342012 @default.
- W2048390434 countsByYear W20483904342013 @default.
- W2048390434 countsByYear W20483904342014 @default.
- W2048390434 countsByYear W20483904342015 @default.
- W2048390434 countsByYear W20483904342016 @default.
- W2048390434 countsByYear W20483904342017 @default.
- W2048390434 countsByYear W20483904342018 @default.
- W2048390434 countsByYear W20483904342019 @default.
- W2048390434 countsByYear W20483904342021 @default.
- W2048390434 countsByYear W20483904342022 @default.
- W2048390434 countsByYear W20483904342023 @default.
- W2048390434 crossrefType "journal-article" @default.
- W2048390434 hasAuthorship W2048390434A5009490514 @default.
- W2048390434 hasAuthorship W2048390434A5031942079 @default.
- W2048390434 hasAuthorship W2048390434A5041984607 @default.
- W2048390434 hasAuthorship W2048390434A5069496269 @default.
- W2048390434 hasConcept C126322002 @default.
- W2048390434 hasConcept C185592680 @default.
- W2048390434 hasConcept C2775832221 @default.
- W2048390434 hasConcept C2777714996 @default.
- W2048390434 hasConcept C2777914695 @default.
- W2048390434 hasConcept C2777961210 @default.
- W2048390434 hasConcept C2778974779 @default.
- W2048390434 hasConcept C501593827 @default.
- W2048390434 hasConcept C55493867 @default.
- W2048390434 hasConcept C71924100 @default.
- W2048390434 hasConceptScore W2048390434C126322002 @default.
- W2048390434 hasConceptScore W2048390434C185592680 @default.
- W2048390434 hasConceptScore W2048390434C2775832221 @default.
- W2048390434 hasConceptScore W2048390434C2777714996 @default.
- W2048390434 hasConceptScore W2048390434C2777914695 @default.
- W2048390434 hasConceptScore W2048390434C2777961210 @default.
- W2048390434 hasConceptScore W2048390434C2778974779 @default.
- W2048390434 hasConceptScore W2048390434C501593827 @default.
- W2048390434 hasConceptScore W2048390434C55493867 @default.
- W2048390434 hasConceptScore W2048390434C71924100 @default.
- W2048390434 hasIssue "3" @default.
- W2048390434 hasLocation W20483904341 @default.
- W2048390434 hasLocation W20483904342 @default.
- W2048390434 hasOpenAccess W2048390434 @default.
- W2048390434 hasPrimaryLocation W20483904341 @default.
- W2048390434 hasRelatedWork W171433666 @default.
- W2048390434 hasRelatedWork W1969660686 @default.
- W2048390434 hasRelatedWork W2048390434 @default.
- W2048390434 hasRelatedWork W2085809094 @default.
- W2048390434 hasRelatedWork W2118429353 @default.
- W2048390434 hasRelatedWork W2163933833 @default.
- W2048390434 hasRelatedWork W2415138818 @default.
- W2048390434 hasRelatedWork W2441567832 @default.
- W2048390434 hasRelatedWork W2470828572 @default.
- W2048390434 hasRelatedWork W4238678312 @default.
- W2048390434 hasVolume "65" @default.
- W2048390434 isParatext "false" @default.
- W2048390434 isRetracted "false" @default.
- W2048390434 magId "2048390434" @default.
- W2048390434 workType "article" @default.