FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048395211> ?p ?o ?g. }

• W2048395211 endingPage "1642" @default.
• W2048395211 startingPage "1637" @default.
• W2048395211 abstract "This study was performed to evaluate the efficacy of peri-interventional treatment with recombinant hirudin (r-hirudin [HBW 023]) compared with heparin in the prevention of troponin T release in patients with unstable angina. Percutaneous transluminal coronary angioplasty in patients with unstable angina is associated with a high risk of acute thrombotic complications. Serial troponin T measurements were performed in 61 patients with unstable angina during the 48-h observation period after coronary angioplasty of the ischemia-related lesion. Patients were randomly assigned to peri-interventional intravenous treatment with either r-hirudin (dosage group I: 0.3-mg/kg body weight bolus, 0.12 mg/kg per h for 24 h; dosage group II: 0.5-mg/kg bolus, 0.24 mg/kg per h for 24 h) or heparin (150-IU/kg bolus, 20 IU/kg per h for 24 h). All patients received acetylsalicylic acid before coronary angiography. After 24 h, patients received a constant low dose infusion of either hirudin (0.04 mg/kg per h) or heparin (7 IU/kg per h) for another 24 h. The power of the study to detect a decrease in abnormal troponin T levels from 60% (heparin group) to 20% (combined r-hirudin groups) was 88%. Serial troponin T measurements revealed two peaks within the 48 h after coronary angioplasty in the heparin but not the hirudin groups. An elevated serum troponin T concentration (>0.2 ng/ml) within 48 h of coronary angioplasty was found in 9 (24%) of 38 patients in the hirudin groups (5 [25%] of 20 in dosage group I; 4 [22%] of 18 in dosage group II) compared with 11 (58%) of 19 in the heparin group (p = 0.01). We observed major cardiac events (death, myocardial infarction, abrupt vessel closure) in 1 (4.8%) of 21 patients in dosage group I, 1 (5.3%) of 19 in dosage group II and 3 (14.3%) of 21 in the heparin group (p = 0.33). In this pilot trial, hirudin appears to be superior to heparin in preventing troponin T release after coronary angioplasty." @default.
• W2048395211 created "2016-06-24" @default.
• W2048395211 creator A5001080720 @default.
• W2048395211 creator A5023687700 @default.
• W2048395211 creator A5023859592 @default.
• W2048395211 creator A5028410198 @default.
• W2048395211 creator A5051578415 @default.
• W2048395211 creator A5055301641 @default.
• W2048395211 creator A5056032715 @default.
• W2048395211 creator A5071887304 @default.
• W2048395211 creator A5078046678 @default.
• W2048395211 creator A5083960788 @default.
• W2048395211 date "1995-12-01" @default.
• W2048395211 modified "2023-09-25" @default.
• W2048395211 title "Recombinant hirudin (HBW 023) prevents troponin T release after coronary angioplasty in patients with unstable angina" @default.
• W2048395211 cites W1947889433 @default.
• W2048395211 cites W1968884705 @default.
• W2048395211 cites W1977398058 @default.
• W2048395211 cites W1977452105 @default.
• W2048395211 cites W1978995142 @default.
• W2048395211 cites W1979698812 @default.
• W2048395211 cites W2006449854 @default.
• W2048395211 cites W2010878652 @default.
• W2048395211 cites W2015041473 @default.
• W2048395211 cites W2021407245 @default.
• W2048395211 cites W2023791250 @default.
• W2048395211 cites W2032302837 @default.
• W2048395211 cites W2044037791 @default.
• W2048395211 cites W2046027264 @default.
• W2048395211 cites W2054824911 @default.
• W2048395211 cites W2058400959 @default.
• W2048395211 cites W2072759532 @default.
• W2048395211 cites W2073214005 @default.
• W2048395211 cites W2077155895 @default.
• W2048395211 cites W2080895142 @default.
• W2048395211 cites W2081527966 @default.
• W2048395211 cites W2087914510 @default.
• W2048395211 cites W2091336880 @default.
• W2048395211 cites W2099363777 @default.
• W2048395211 cites W2105448511 @default.
• W2048395211 cites W2106349347 @default.
• W2048395211 cites W2109652687 @default.
• W2048395211 cites W2110385373 @default.
• W2048395211 cites W2138849164 @default.
• W2048395211 cites W2160541694 @default.
• W2048395211 cites W2236494390 @default.
• W2048395211 cites W2312652910 @default.
• W2048395211 cites W2335915210 @default.
• W2048395211 cites W2340237670 @default.
• W2048395211 cites W2340638737 @default.
• W2048395211 cites W2413674647 @default.
• W2048395211 cites W2417899551 @default.
• W2048395211 cites W2433173101 @default.
• W2048395211 cites W2477808709 @default.
• W2048395211 cites W4245105995 @default.
• W2048395211 doi "https://doi.org/10.1016/0735-1097(95)00371-1" @default.
• W2048395211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7594097" @default.
• W2048395211 hasPublicationYear "1995" @default.
• W2048395211 type Work @default.
• W2048395211 sameAs 2048395211 @default.
• W2048395211 citedByCount "47" @default.
• W2048395211 countsByYear W20483952112021 @default.
• W2048395211 crossrefType "journal-article" @default.
• W2048395211 hasAuthorship W2048395211A5001080720 @default.
• W2048395211 hasAuthorship W2048395211A5023687700 @default.
• W2048395211 hasAuthorship W2048395211A5023859592 @default.
• W2048395211 hasAuthorship W2048395211A5028410198 @default.
• W2048395211 hasAuthorship W2048395211A5051578415 @default.
• W2048395211 hasAuthorship W2048395211A5055301641 @default.
• W2048395211 hasAuthorship W2048395211A5056032715 @default.
• W2048395211 hasAuthorship W2048395211A5071887304 @default.
• W2048395211 hasAuthorship W2048395211A5078046678 @default.
• W2048395211 hasAuthorship W2048395211A5083960788 @default.
• W2048395211 hasBestOaLocation W20483952111 @default.
• W2048395211 hasConcept C126322002 @default.
• W2048395211 hasConcept C144469398 @default.
• W2048395211 hasConcept C164705383 @default.
• W2048395211 hasConcept C2777292125 @default.
• W2048395211 hasConcept C2777557582 @default.
• W2048395211 hasConcept C2777785093 @default.
• W2048395211 hasConcept C2778205648 @default.
• W2048395211 hasConcept C2778271848 @default.
• W2048395211 hasConcept C2778425758 @default.
• W2048395211 hasConcept C2779581417 @default.
• W2048395211 hasConcept C2780326628 @default.
• W2048395211 hasConcept C36036425 @default.
• W2048395211 hasConcept C42219234 @default.
• W2048395211 hasConcept C43376680 @default.
• W2048395211 hasConcept C500558357 @default.
• W2048395211 hasConcept C71924100 @default.
• W2048395211 hasConcept C89560881 @default.
• W2048395211 hasConceptScore W2048395211C126322002 @default.
• W2048395211 hasConceptScore W2048395211C144469398 @default.
• W2048395211 hasConceptScore W2048395211C164705383 @default.
• W2048395211 hasConceptScore W2048395211C2777292125 @default.
• W2048395211 hasConceptScore W2048395211C2777557582 @default.
• W2048395211 hasConceptScore W2048395211C2777785093 @default.
• W2048395211 hasConceptScore W2048395211C2778205648 @default.

• next