Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048400736> ?p ?o ?g. }
- W2048400736 endingPage "e1001808" @default.
- W2048400736 startingPage "e1001808" @default.
- W2048400736 abstract "Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial cells, is regulated during the ovarian cycle and promotes axonal sprouting in hypothalamic neurons secreting gonadotropin-releasing hormone (GnRH), the neuropeptide controlling reproduction. Both the inhibition of Sema3A/Nrp1 signaling and the conditional deletion of Nrp1 in GnRH neurons counteract Sema3A-induced axonal sprouting. Furthermore, the localized intracerebral infusion of Nrp1- or Sema3A-neutralizing antibodies in vivo disrupts the ovarian cycle. Finally, the selective neutralization of endothelial-cell Sema3A signaling in adult Sema3aloxP/loxP mice by the intravenous injection of the recombinant TAT-Cre protein alters the amplitude of the preovulatory luteinizing hormone surge, likely by perturbing GnRH release into the hypothalamo-hypophyseal portal system. Our results identify a previously unknown function for 65 kDa Sema3A-Nrp1 signaling in the induction of axonal growth, and raise the possibility that endothelial cells actively participate in synaptic plasticity in specific functional domains of the adult central nervous system, thus controlling key physiological functions such as reproduction." @default.
- W2048400736 created "2016-06-24" @default.
- W2048400736 creator A5004791939 @default.
- W2048400736 creator A5005112202 @default.
- W2048400736 creator A5010731522 @default.
- W2048400736 creator A5021096415 @default.
- W2048400736 creator A5025381974 @default.
- W2048400736 creator A5025844013 @default.
- W2048400736 creator A5030288066 @default.
- W2048400736 creator A5037739308 @default.
- W2048400736 creator A5042259464 @default.
- W2048400736 creator A5046382080 @default.
- W2048400736 creator A5054510775 @default.
- W2048400736 creator A5058705393 @default.
- W2048400736 creator A5060733104 @default.
- W2048400736 creator A5065090444 @default.
- W2048400736 creator A5066177154 @default.
- W2048400736 creator A5071161962 @default.
- W2048400736 creator A5071208511 @default.
- W2048400736 creator A5083058332 @default.
- W2048400736 creator A5091370990 @default.
- W2048400736 date "2014-03-11" @default.
- W2048400736 modified "2023-10-16" @default.
- W2048400736 title "Brain Endothelial Cells Control Fertility through Ovarian-Steroid–Dependent Release of Semaphorin 3A" @default.
- W2048400736 cites W1269376548 @default.
- W2048400736 cites W1607895415 @default.
- W2048400736 cites W1632145855 @default.
- W2048400736 cites W1854865760 @default.
- W2048400736 cites W1969356938 @default.
- W2048400736 cites W1969689291 @default.
- W2048400736 cites W1975627280 @default.
- W2048400736 cites W1976020443 @default.
- W2048400736 cites W1980638243 @default.
- W2048400736 cites W1982008460 @default.
- W2048400736 cites W1983035958 @default.
- W2048400736 cites W1990983421 @default.
- W2048400736 cites W1994088328 @default.
- W2048400736 cites W2003975080 @default.
- W2048400736 cites W2005215351 @default.
- W2048400736 cites W2008034949 @default.
- W2048400736 cites W2008516083 @default.
- W2048400736 cites W2008661951 @default.
- W2048400736 cites W2013184812 @default.
- W2048400736 cites W2013281213 @default.
- W2048400736 cites W2016617827 @default.
- W2048400736 cites W2019071853 @default.
- W2048400736 cites W2024663378 @default.
- W2048400736 cites W2025078194 @default.
- W2048400736 cites W2030585597 @default.
- W2048400736 cites W2031632319 @default.
- W2048400736 cites W2033116719 @default.
- W2048400736 cites W2035799281 @default.
- W2048400736 cites W2036380584 @default.
- W2048400736 cites W2037217928 @default.
- W2048400736 cites W2041700814 @default.
- W2048400736 cites W2042952122 @default.
- W2048400736 cites W2043732175 @default.
- W2048400736 cites W2051130488 @default.
- W2048400736 cites W2055613750 @default.
- W2048400736 cites W2058596914 @default.
- W2048400736 cites W2065118621 @default.
- W2048400736 cites W2067244055 @default.
- W2048400736 cites W2068599628 @default.
- W2048400736 cites W2071241028 @default.
- W2048400736 cites W2074275713 @default.
- W2048400736 cites W2075313905 @default.
- W2048400736 cites W2085821206 @default.
- W2048400736 cites W2090543474 @default.
- W2048400736 cites W2095931805 @default.
- W2048400736 cites W2095933610 @default.
- W2048400736 cites W2098767045 @default.
- W2048400736 cites W2107916607 @default.
- W2048400736 cites W2108819835 @default.
- W2048400736 cites W2114506814 @default.
- W2048400736 cites W2115167653 @default.
- W2048400736 cites W2116721266 @default.
- W2048400736 cites W2125063573 @default.
- W2048400736 cites W2127857891 @default.
- W2048400736 cites W2141115613 @default.
- W2048400736 cites W2147435582 @default.
- W2048400736 cites W2156925845 @default.
- W2048400736 cites W3023672242 @default.
- W2048400736 cites W4249871697 @default.
- W2048400736 doi "https://doi.org/10.1371/journal.pbio.1001808" @default.
- W2048400736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3949669" @default.
- W2048400736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24618750" @default.
- W2048400736 hasPublicationYear "2014" @default.
- W2048400736 type Work @default.
- W2048400736 sameAs 2048400736 @default.
- W2048400736 citedByCount "52" @default.
- W2048400736 countsByYear W20484007362014 @default.
- W2048400736 countsByYear W20484007362015 @default.
- W2048400736 countsByYear W20484007362016 @default.
- W2048400736 countsByYear W20484007362017 @default.
- W2048400736 countsByYear W20484007362018 @default.
- W2048400736 countsByYear W20484007362019 @default.
- W2048400736 countsByYear W20484007362020 @default.
- W2048400736 countsByYear W20484007362021 @default.