FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048403168> ?p ?o ?g. }

• W2048403168 endingPage "34" @default.
• W2048403168 startingPage "29" @default.
• W2048403168 abstract "To evaluate the potential of an animal model as a means to identify bone-targeted estrogens, we have studied the response of the skeleton of ovariectomized mice to prolonged estrogen treatment. Seventy female Swiss-Webster mice were randomly divided into ten groups, with nine groups undergoing bilateral ovariectomy and one group a sham procedure. Mice were injected subcutaneously once per week for nine weeks with one of the following doses of estrogen (17β-E2) in oil vehicle: 19.3, 38.5, 75, 150, 300, 500, 1000, or 3000 μg. One group of ovariectomized (OVX) mice and the sham operated animals received vehicle injections only. At the end of the nine-week experimental protocol, there were no significant differences in body weights among any treatment groups. However, when compared to control values, spleen weights in vehicle-treated OVX mice and in mice treated with 1000 μg or 3000 μg of 17β-E2 were significantly elevated (p < .01). Liver weights in the OVX mice treated with 1000 or 3000 μg 17β-E2 were also increased significantly (p < .05). Comparisons of uterine weights and cortical bone areas were strongly correlated with 17β-E2 dose (r2 = .86 and .94, respectively), with maximal increases observed at estradiol doses in excess of 500 μg per week. Furthermore, based on bone histomorphometry of in vivo fluorochrome labels, increases in cortical bone area could be attributed to accelerated rates of endosteal mineral apposition and bone formation. These results indicate that the comparison of the response of endosteal bone and uterine tissue in the OVX mice to chronic estrogen treatment offers the potential to identify estrogen and/or estrogen-like compounds with bone-specific activity." @default.
• W2048403168 created "2016-06-24" @default.
• W2048403168 creator A5016241917 @default.
• W2048403168 creator A5019487775 @default.
• W2048403168 creator A5044759164 @default.
• W2048403168 creator A5062498760 @default.
• W2048403168 creator A5086207117 @default.
• W2048403168 date "1992-01-01" @default.
• W2048403168 modified "2023-10-10" @default.
• W2048403168 title "17β Estradiol stimulation of endosteal bone formation in the ovariectomized mouse: An animal model for the evaluation of bone-targeted estrogens" @default.
• W2048403168 cites W1532749597 @default.
• W2048403168 cites W1822871321 @default.
• W2048403168 cites W1976104407 @default.
• W2048403168 cites W1983571603 @default.
• W2048403168 cites W1996758205 @default.
• W2048403168 cites W2007223217 @default.
• W2048403168 cites W2019308648 @default.
• W2048403168 cites W2024785950 @default.
• W2048403168 cites W2030525320 @default.
• W2048403168 cites W2046983302 @default.
• W2048403168 cites W2051390660 @default.
• W2048403168 cites W2052858021 @default.
• W2048403168 cites W2062729355 @default.
• W2048403168 cites W2063949986 @default.
• W2048403168 cites W2076408697 @default.
• W2048403168 cites W2079170574 @default.
• W2048403168 cites W2080038460 @default.
• W2048403168 cites W2083744069 @default.
• W2048403168 cites W2092791248 @default.
• W2048403168 cites W2094834328 @default.
• W2048403168 cites W2109228066 @default.
• W2048403168 cites W2131914226 @default.
• W2048403168 cites W2140086733 @default.
• W2048403168 cites W2154721664 @default.
• W2048403168 cites W2230734102 @default.
• W2048403168 cites W2237539561 @default.
• W2048403168 cites W2304520185 @default.
• W2048403168 cites W2322980100 @default.
• W2048403168 cites W2421421521 @default.
• W2048403168 cites W2499835576 @default.
• W2048403168 cites W2742718982 @default.
• W2048403168 cites W2794733737 @default.
• W2048403168 cites W340680525 @default.
• W2048403168 cites W2105727025 @default.
• W2048403168 doi "https://doi.org/10.1016/8756-3282(92)90358-4" @default.
• W2048403168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1581106" @default.
• W2048403168 hasPublicationYear "1992" @default.
• W2048403168 type Work @default.
• W2048403168 sameAs 2048403168 @default.
• W2048403168 citedByCount "81" @default.
• W2048403168 countsByYear W20484031682012 @default.
• W2048403168 countsByYear W20484031682013 @default.
• W2048403168 countsByYear W20484031682014 @default.
• W2048403168 countsByYear W20484031682015 @default.
• W2048403168 countsByYear W20484031682016 @default.
• W2048403168 countsByYear W20484031682017 @default.
• W2048403168 countsByYear W20484031682019 @default.
• W2048403168 countsByYear W20484031682020 @default.
• W2048403168 countsByYear W20484031682021 @default.
• W2048403168 countsByYear W20484031682022 @default.
• W2048403168 countsByYear W20484031682023 @default.
• W2048403168 crossrefType "journal-article" @default.
• W2048403168 hasAuthorship W2048403168A5016241917 @default.
• W2048403168 hasAuthorship W2048403168A5019487775 @default.
• W2048403168 hasAuthorship W2048403168A5044759164 @default.
• W2048403168 hasAuthorship W2048403168A5062498760 @default.
• W2048403168 hasAuthorship W2048403168A5086207117 @default.
• W2048403168 hasConcept C105702510 @default.
• W2048403168 hasConcept C117866178 @default.
• W2048403168 hasConcept C126322002 @default.
• W2048403168 hasConcept C134018914 @default.
• W2048403168 hasConcept C185592680 @default.
• W2048403168 hasConcept C24998067 @default.
• W2048403168 hasConcept C2776541429 @default.
• W2048403168 hasConcept C2776886416 @default.
• W2048403168 hasConcept C2777164284 @default.
• W2048403168 hasConcept C2781451080 @default.
• W2048403168 hasConcept C71924100 @default.
• W2048403168 hasConcept C8264082 @default.
• W2048403168 hasConceptScore W2048403168C105702510 @default.
• W2048403168 hasConceptScore W2048403168C117866178 @default.
• W2048403168 hasConceptScore W2048403168C126322002 @default.
• W2048403168 hasConceptScore W2048403168C134018914 @default.
• W2048403168 hasConceptScore W2048403168C185592680 @default.
• W2048403168 hasConceptScore W2048403168C24998067 @default.
• W2048403168 hasConceptScore W2048403168C2776541429 @default.
• W2048403168 hasConceptScore W2048403168C2776886416 @default.
• W2048403168 hasConceptScore W2048403168C2777164284 @default.
• W2048403168 hasConceptScore W2048403168C2781451080 @default.
• W2048403168 hasConceptScore W2048403168C71924100 @default.
• W2048403168 hasConceptScore W2048403168C8264082 @default.
• W2048403168 hasIssue "1" @default.
• W2048403168 hasLocation W20484031681 @default.
• W2048403168 hasLocation W20484031682 @default.
• W2048403168 hasOpenAccess W2048403168 @default.
• W2048403168 hasPrimaryLocation W20484031681 @default.
• W2048403168 hasRelatedWork W2047473481 @default.
• W2048403168 hasRelatedWork W2060518983 @default.

• next