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• W2048403952 abstract "Significance Women are more susceptible to multiple sclerosis (MS), but men demonstrate a more progressive disease course. In the MS model, experimental autoimmune encephalomyelitis (EAE), XX as compared with XY, conferred greater encephalitogenic responses. Here, we examined effects of sex chromosomes in the CNS using bone marrow chimeras with XX versus XY CNS and immune systems of the same sex chromosomal type. EAE mice with XY CNS, compared with XX, demonstrated more severe clinical disease with more neurodegeneration in the spinal cord, cerebellum, and cerebral cortex. Expression of the X gene toll-like receptor 7 , known to induce neuronal damage, was increased in XY mice. These results may bring insight into why men progress faster during a disease characterized by increased susceptibility in women." @default.
• W2048403952 created "2016-06-24" @default.
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• W2048403952 date "2014-02-03" @default.
• W2048403952 modified "2023-10-17" @default.
• W2048403952 title "XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis" @default.
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• W2048403952 doi "https://doi.org/10.1073/pnas.1307091111" @default.
• W2048403952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3932937" @default.
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• W2048403952 hasPublicationYear "2014" @default.
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