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- W2048409924 abstract "Phospholipids are complex and varied biomolecules that are susceptible to lipid peroxidation after attack by free radicals or electrophilic oxidants and can yield a large number of different oxidation products. There are many available methods for detecting phospholipid oxidation products, but also various limitations and problems. Electrospray ionization mass spectrometry allows the simultaneous but specific analysis of multiple species with good sensitivity and has a further advantage that it can be coupled to liquid chromatography for separation of oxidation products. Here, we explain the principles of oxidized phospholipid analysis by electrospray mass spectrometry and describe fragmentation routines for surveying the structural properties of the analytes, in particular precursor ion and neutral loss scanning. These allow targeted detection of phospholipid headgroups and identification of phospholipids containing hydroperoxides and chlorine, as well as the detection of some individual oxidation products by their specific fragmentation patterns. We describe instrument protocols for carrying out these survey routines on a QTrap5500 mass spectrometer and also for interfacing with reverse-phase liquid chromatography. The article highlights critical aspects of the analysis as well as some limitations of the methodology." @default.
- W2048409924 created "2016-06-24" @default.
- W2048409924 creator A5007439444 @default.
- W2048409924 creator A5035356657 @default.
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- W2048409924 date "2011-12-01" @default.
- W2048409924 modified "2023-10-01" @default.
- W2048409924 title "Identification of oxidized phospholipids by electrospray ionization mass spectrometry and LC–MS using a QQLIT instrument" @default.
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- W2048409924 doi "https://doi.org/10.1016/j.freeradbiomed.2011.09.003" @default.
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