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- W2048410040 abstract "A set of novel borrelidin analogues have been prepared by precursor-directed biosynthesis. Structure-activity relationship analysis suggests that steric structural arrangement within the C17 side chain is important for differentiating cytotoxic and anti-angiogenic activities. A C17-cyclobutyl analogue 3 was found to have markedly increased selectivity for in vitro angiogenesis inhibition over cytotoxicity and is therefore potentially useful as an anticancer agent." @default.
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- W2048410040 date "2006-11-01" @default.
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- W2048410040 title "Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain" @default.
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- W2048410040 doi "https://doi.org/10.1016/j.bmcl.2006.08.073" @default.
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