Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048411565> ?p ?o ?g. }
- W2048411565 endingPage "77" @default.
- W2048411565 startingPage "67" @default.
- W2048411565 abstract "Ependymal cells form the walls of the ventricles, and take part in the production of cerebrospinal fluid (CSF). Aquaporin-4 (AQP4), a predominant water channel of the brain, is restricted to basolateral plasma membranes of ependymal cells. The highly polarized expression of AQP4 suggests it may be involved in maintaining the structural and functional integrity of the ependyma. This hypothesis was validated by using adult AQP4 knockout mice generated by our laboratory [Fan Y, Zhang J, Sun XL, Gao L, Zeng XN, Ding JH, Cao C, Niu L, Hu G (2005) Sex- and region-specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin-4 knockout mice. J Neurosci Res 82:458-464]. Histological analysis showed disorganized ependymal layer of the lateral ventricle and aqueduct in AQP4-deficiency mice. A majority (92.7%) of null mice displayed reduced lateral ventricular volume, while a small fraction (7.3%) had enlarged or normal ventricular size with a narrow aqueduct. Immunohistochemistry demonstrated that AQP4 deletion resulted in decreased expression of gap junction protein connexin43 in the ependymal cells. Electron microscopy confirmed junctional complex absence at basolateral membranes of ependymocytes. Moreover, AQP4 knockout mice showed decreased CSF production and increased brain water content compared with wild-type mice. These results highlight a key role of AQP4 in maintaining the structure and function of the ependyma. In addition, variable profiles of ventricle system in adult AQP4 null mice indicate functional AQP4 polymorphisms." @default.
- W2048411565 created "2016-06-24" @default.
- W2048411565 creator A5013586047 @default.
- W2048411565 creator A5013777006 @default.
- W2048411565 creator A5031979422 @default.
- W2048411565 creator A5032644366 @default.
- W2048411565 creator A5065046382 @default.
- W2048411565 creator A5080015166 @default.
- W2048411565 date "2009-08-01" @default.
- W2048411565 modified "2023-10-14" @default.
- W2048411565 title "Aquaporin-4 maintains ependymal integrity in adult mice" @default.
- W2048411565 cites W1495656315 @default.
- W2048411565 cites W1535419310 @default.
- W2048411565 cites W1551925364 @default.
- W2048411565 cites W1831896296 @default.
- W2048411565 cites W1963576357 @default.
- W2048411565 cites W1963614683 @default.
- W2048411565 cites W1967610434 @default.
- W2048411565 cites W1971597564 @default.
- W2048411565 cites W1975127949 @default.
- W2048411565 cites W1975592146 @default.
- W2048411565 cites W1982084400 @default.
- W2048411565 cites W1993064394 @default.
- W2048411565 cites W1993258467 @default.
- W2048411565 cites W1997574055 @default.
- W2048411565 cites W2001178402 @default.
- W2048411565 cites W2001613505 @default.
- W2048411565 cites W2004915376 @default.
- W2048411565 cites W2010395737 @default.
- W2048411565 cites W2012893265 @default.
- W2048411565 cites W2034809729 @default.
- W2048411565 cites W2040300306 @default.
- W2048411565 cites W2048761373 @default.
- W2048411565 cites W2052414593 @default.
- W2048411565 cites W2059028264 @default.
- W2048411565 cites W2064057102 @default.
- W2048411565 cites W2064803491 @default.
- W2048411565 cites W2066840018 @default.
- W2048411565 cites W2074809613 @default.
- W2048411565 cites W2079574769 @default.
- W2048411565 cites W2083785381 @default.
- W2048411565 cites W2084721170 @default.
- W2048411565 cites W2086158333 @default.
- W2048411565 cites W2091798235 @default.
- W2048411565 cites W2095093937 @default.
- W2048411565 cites W2098157576 @default.
- W2048411565 cites W2111534880 @default.
- W2048411565 cites W2111814389 @default.
- W2048411565 cites W2113184411 @default.
- W2048411565 cites W2114771850 @default.
- W2048411565 cites W2122434387 @default.
- W2048411565 cites W2124292468 @default.
- W2048411565 cites W2134189805 @default.
- W2048411565 cites W2134483650 @default.
- W2048411565 cites W2139230166 @default.
- W2048411565 cites W2151305004 @default.
- W2048411565 cites W2153759921 @default.
- W2048411565 cites W2153978690 @default.
- W2048411565 cites W2170463631 @default.
- W2048411565 cites W2172238479 @default.
- W2048411565 doi "https://doi.org/10.1016/j.neuroscience.2009.04.044" @default.
- W2048411565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19393298" @default.
- W2048411565 hasPublicationYear "2009" @default.
- W2048411565 type Work @default.
- W2048411565 sameAs 2048411565 @default.
- W2048411565 citedByCount "65" @default.
- W2048411565 countsByYear W20484115652012 @default.
- W2048411565 countsByYear W20484115652013 @default.
- W2048411565 countsByYear W20484115652014 @default.
- W2048411565 countsByYear W20484115652016 @default.
- W2048411565 countsByYear W20484115652018 @default.
- W2048411565 countsByYear W20484115652019 @default.
- W2048411565 countsByYear W20484115652020 @default.
- W2048411565 countsByYear W20484115652021 @default.
- W2048411565 countsByYear W20484115652022 @default.
- W2048411565 countsByYear W20484115652023 @default.
- W2048411565 crossrefType "journal-article" @default.
- W2048411565 hasAuthorship W2048411565A5013586047 @default.
- W2048411565 hasAuthorship W2048411565A5013777006 @default.
- W2048411565 hasAuthorship W2048411565A5031979422 @default.
- W2048411565 hasAuthorship W2048411565A5032644366 @default.
- W2048411565 hasAuthorship W2048411565A5065046382 @default.
- W2048411565 hasAuthorship W2048411565A5080015166 @default.
- W2048411565 hasConcept C104317684 @default.
- W2048411565 hasConcept C105702510 @default.
- W2048411565 hasConcept C126322002 @default.
- W2048411565 hasConcept C127716648 @default.
- W2048411565 hasConcept C134018914 @default.
- W2048411565 hasConcept C142724271 @default.
- W2048411565 hasConcept C15755913 @default.
- W2048411565 hasConcept C164659718 @default.
- W2048411565 hasConcept C169760540 @default.
- W2048411565 hasConcept C170493617 @default.
- W2048411565 hasConcept C182704531 @default.
- W2048411565 hasConcept C2776663378 @default.
- W2048411565 hasConcept C2779651940 @default.
- W2048411565 hasConcept C2780744974 @default.
- W2048411565 hasConcept C2909073510 @default.