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• W2048419355 endingPage "332" @default.
• W2048419355 startingPage "329" @default.
• W2048419355 abstract "Amyloid precursor protein (APP) gene expression was investigated in primary cultures of neurons, astrocytes, microglial cells and oligodendrocytes. Neurons from various rat brain regions, as well as oligodendrocytes, contained RNA encoding APP695, while astrocytes and microglial cells expressed high levels of RNAs for APP770 and APP751. It was studied whether the cell type-specific regulation of APP gene expression could be modified by induction of cellular differentiation in vitro. While neuronal differentiation of PC12 cells has been shown to correspond with an altered pattern of APP splicing, in the primary cultures neither the time in culture nor a treatment of the cells with appropriate differentiation factors affected this pattern." @default.
• W2048419355 created "2016-06-24" @default.
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• W2048419355 date "1992-08-03" @default.
• W2048419355 modified "2023-09-25" @default.
• W2048419355 title "APP RNA splicing is not affected by differentiation of neurons and glia in culture" @default.
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• W2048419355 doi "https://doi.org/10.1016/0014-5793(92)80706-m" @default.
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• W2048419355 hasPublicationYear "1992" @default.
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