Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048428229> ?p ?o ?g. }
- W2048428229 endingPage "90" @default.
- W2048428229 startingPage "82" @default.
- W2048428229 abstract "Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 (EHEC) form characteristic lesions on infected mammalian cells called actin pedestals. Each of these two pathogens injects its own translocated intimin receptor (Tir) molecule into the plasma membranes of host cells. Interaction of translocated Tir with the bacterial outer membrane protein intimin is required to trigger the assembly of actin into focused pedestals beneath bound bacteria. Despite similarities between the Tir molecules and the host components that associate with pedestals, recent work indicates that EPEC and EHEC Tir are not functionally interchangeable. For EPEC, Tir-mediated binding of Nck, a host adaptor protein implicated in actin signaling, is both necessary and sufficient to initiate actin assembly. In contrast, for EHEC, pedestals are formed independently of Nck, and require translocation of bacterial factors in addition to Tir to trigger actin signaling." @default.
- W2048428229 created "2016-06-24" @default.
- W2048428229 creator A5021283191 @default.
- W2048428229 creator A5031816004 @default.
- W2048428229 date "2003-02-01" @default.
- W2048428229 modified "2023-10-03" @default.
- W2048428229 title "Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7" @default.
- W2048428229 cites W1492600174 @default.
- W2048428229 cites W1500563098 @default.
- W2048428229 cites W1507572058 @default.
- W2048428229 cites W1532955427 @default.
- W2048428229 cites W1564861448 @default.
- W2048428229 cites W1593929303 @default.
- W2048428229 cites W1634254630 @default.
- W2048428229 cites W1672147349 @default.
- W2048428229 cites W1764369073 @default.
- W2048428229 cites W1834621352 @default.
- W2048428229 cites W1842457711 @default.
- W2048428229 cites W1857478421 @default.
- W2048428229 cites W1859520518 @default.
- W2048428229 cites W1867023482 @default.
- W2048428229 cites W1944236476 @default.
- W2048428229 cites W1959594413 @default.
- W2048428229 cites W1960167042 @default.
- W2048428229 cites W1966081550 @default.
- W2048428229 cites W1966487254 @default.
- W2048428229 cites W1966948348 @default.
- W2048428229 cites W1982643313 @default.
- W2048428229 cites W1983344225 @default.
- W2048428229 cites W1983346062 @default.
- W2048428229 cites W1986775095 @default.
- W2048428229 cites W2014742892 @default.
- W2048428229 cites W2020422209 @default.
- W2048428229 cites W2020691322 @default.
- W2048428229 cites W2025728213 @default.
- W2048428229 cites W2028193297 @default.
- W2048428229 cites W2036436474 @default.
- W2048428229 cites W2038261860 @default.
- W2048428229 cites W2039457979 @default.
- W2048428229 cites W2044084413 @default.
- W2048428229 cites W2045765967 @default.
- W2048428229 cites W2053607459 @default.
- W2048428229 cites W2055120082 @default.
- W2048428229 cites W2061828721 @default.
- W2048428229 cites W2064406341 @default.
- W2048428229 cites W2081227459 @default.
- W2048428229 cites W2087298251 @default.
- W2048428229 cites W2088340544 @default.
- W2048428229 cites W2089854636 @default.
- W2048428229 cites W2091058158 @default.
- W2048428229 cites W2098957993 @default.
- W2048428229 cites W2099544870 @default.
- W2048428229 cites W2099768150 @default.
- W2048428229 cites W2099836442 @default.
- W2048428229 cites W2102685414 @default.
- W2048428229 cites W2105503408 @default.
- W2048428229 cites W2107201436 @default.
- W2048428229 cites W2124346271 @default.
- W2048428229 cites W2127383168 @default.
- W2048428229 cites W2127912613 @default.
- W2048428229 cites W2128041563 @default.
- W2048428229 cites W2132068517 @default.
- W2048428229 cites W2138225582 @default.
- W2048428229 cites W2146055612 @default.
- W2048428229 cites W2151397718 @default.
- W2048428229 cites W2152869773 @default.
- W2048428229 cites W2153937997 @default.
- W2048428229 cites W2155121556 @default.
- W2048428229 cites W2157116022 @default.
- W2048428229 cites W2158757814 @default.
- W2048428229 cites W2162795346 @default.
- W2048428229 cites W2173338776 @default.
- W2048428229 cites W45421301 @default.
- W2048428229 doi "https://doi.org/10.1016/s1369-5274(03)00005-5" @default.
- W2048428229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12615225" @default.
- W2048428229 hasPublicationYear "2003" @default.
- W2048428229 type Work @default.
- W2048428229 sameAs 2048428229 @default.
- W2048428229 citedByCount "144" @default.
- W2048428229 countsByYear W20484282292012 @default.
- W2048428229 countsByYear W20484282292013 @default.
- W2048428229 countsByYear W20484282292014 @default.
- W2048428229 countsByYear W20484282292015 @default.
- W2048428229 countsByYear W20484282292016 @default.
- W2048428229 countsByYear W20484282292017 @default.
- W2048428229 countsByYear W20484282292018 @default.
- W2048428229 countsByYear W20484282292019 @default.
- W2048428229 countsByYear W20484282292021 @default.
- W2048428229 countsByYear W20484282292022 @default.
- W2048428229 countsByYear W20484282292023 @default.
- W2048428229 crossrefType "journal-article" @default.
- W2048428229 hasAuthorship W2048428229A5021283191 @default.
- W2048428229 hasAuthorship W2048428229A5031816004 @default.
- W2048428229 hasConcept C104317684 @default.
- W2048428229 hasConcept C118815799 @default.
- W2048428229 hasConcept C125705527 @default.
- W2048428229 hasConcept C146587185 @default.
- W2048428229 hasConcept C183786373 @default.