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- W2048436327 abstract "Analysis of the distribution of RNA double labeled with [14C]- and [3H]orotic acid in ribosomal particles separated by sucrose density-gradient centrifugation and the selective dissociation of unprogrammed ribosomes showed that the increase in proportion of monomeric ribosomes caused by hypothermia is due entirely to the increase in the unprogrammed ribosome fraction at the expense of polyribosomes. Protein synthetic activities of polyribosomes in vivo in livers of hypothermic and control mice were compared by double labeling of nascent and soluble polypeptides with [14C]- and [3H]leucine. Incorporation of radioactivity was relatively higher in nascent polypeptides and lower in soluble polypeptides in hypothermic than in control mice. The results indicate that hypothermia affects protein synthesis in livers of mice by decreasing probably the rates of both initiation and elongation, but affecting the former more than the latter." @default.
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- W2048436327 date "1978-06-01" @default.
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- W2048436327 title "Alteration of hepatic polyribosome structure and function in mice during hypothermia" @default.
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- W2048436327 doi "https://doi.org/10.1016/0014-4800(78)90011-4" @default.
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