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- W2048436334 abstract "Six patients were diagnosed as having acute promyelocytic leukemia (APL) according to FAB criteria. One patient conformed to the M3 variant. Informative cytogenetic results (G-banding) on five of the patients showed that three of them, including the M3 variant, had the 15;17 translocation in bone-marrow or blood cells. Cells with the translocation were accompanied by cells with a normal karyotype in all patients and no other chromosomal abnormality was present. This first report of the 15;17 translocation from the South Pacific region is relevant to the uneven geographical distribution of APL patients with the translocation. Five of the six patients, including the M3 variant, showed a distinctive pattern of cell growth in agar culture characterized by a profusion of small, uniform clusters containing 6–20 cells with the appearance of promyelocytes. The remaining patient had a pattern of cell growth more typical of M2 acute leukemia. This cell growth pattern may be useful in diagnosing and monitoring the course of APL." @default.
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- W2048436334 date "1981-02-15" @default.
- W2048436334 modified "2023-09-26" @default.
- W2048436334 title "Acute promyelocytic leukemia: Cytogenetics and bone-marrow culture" @default.
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- W2048436334 doi "https://doi.org/10.1002/ijc.2910270207" @default.
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