FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048440069> ?p ?o ?g. }

• W2048440069 endingPage "505" @default.
• W2048440069 startingPage "493" @default.
• W2048440069 abstract "Parathyroid hormone-related protein (PTHrP) is an autocrine/paracrine factor produced by breast cancer cells that is speculated to play a major role in permitting breast cancer cells to grow into the bone microenvironment by stimulating the bone resorption axis. It has been previously shown that EGFR signaling induces the production of PTHrP in several primary and transformed epithelial cell types. Therefore, we investigated the relationship between EGFR and PTHrP gene expression in human breast cancer cells. Of a panel of 7 breast epithelial and cancer cell lines, the osteolytic, EGFR- positive lines (MDA-MB-231 and NS2T2A1) exhibited higher levels of PTHrP transcript expression. Amphiregulin mRNA levels in all lines were approximately 2 orders of magnitude higher than those of TGFα or HB-EGF. In the EGFR bearing lines, the receptor was phosphorylated at tyrosine 992 under basal conditions, and the addition of 100 nM amphiregulin did not lead to the phosphorylation of other tyrosine residues typically phosphorylated by the prototypical ligand EGF. Treatment of the EGFR positive lines with the EGFR inhibitor PD153035 and amphiregulin-neutralizing antibodies reduced PTHrP mRNA levels by 50–70%. Stable EGFR expression in the MCF7 line failed to increase basal PTHrP mRNA levels; however, treatment of this cell line with exogenous EGF or amphiregulin increased PTHrP transcription 3-fold. Transient transfection analysis suggests that the MAPK pathway and ETS transcription factors mediate EGFR coupling to PTHrP gene expression. Taken together, it appears that autocrine stimulation of EGFR signaling by amphiregulin is coupled to PTHrP gene expression via EGFR Tyr992 and MAPK, and that this pathway may contribute to PTHrP expression by breast tumor cells." @default.
• W2048440069 created "2016-06-24" @default.
• W2048440069 creator A5007017426 @default.
• W2048440069 creator A5027738013 @default.
• W2048440069 creator A5029314163 @default.
• W2048440069 creator A5047347828 @default.
• W2048440069 creator A5060806761 @default.
• W2048440069 creator A5065201703 @default.
• W2048440069 creator A5088579585 @default.
• W2048440069 date "2007-09-20" @default.
• W2048440069 modified "2023-10-03" @default.
• W2048440069 title "Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells" @default.
• W2048440069 cites W1510900532 @default.
• W2048440069 cites W1720535299 @default.
• W2048440069 cites W1797037641 @default.
• W2048440069 cites W1940826359 @default.
• W2048440069 cites W1965434694 @default.
• W2048440069 cites W1968231448 @default.
• W2048440069 cites W1970862625 @default.
• W2048440069 cites W1979016878 @default.
• W2048440069 cites W1988901915 @default.
• W2048440069 cites W1991486724 @default.
• W2048440069 cites W1994575948 @default.
• W2048440069 cites W1997688114 @default.
• W2048440069 cites W1998269329 @default.
• W2048440069 cites W2010105399 @default.
• W2048440069 cites W2013284147 @default.
• W2048440069 cites W2013899180 @default.
• W2048440069 cites W2015833571 @default.
• W2048440069 cites W2018171662 @default.
• W2048440069 cites W2023106260 @default.
• W2048440069 cites W2023188630 @default.
• W2048440069 cites W2030798978 @default.
• W2048440069 cites W2032708781 @default.
• W2048440069 cites W2034117677 @default.
• W2048440069 cites W2035976340 @default.
• W2048440069 cites W2041584626 @default.
• W2048440069 cites W2043911313 @default.
• W2048440069 cites W2057994540 @default.
• W2048440069 cites W2058646964 @default.
• W2048440069 cites W2063380069 @default.
• W2048440069 cites W2063406923 @default.
• W2048440069 cites W2063699543 @default.
• W2048440069 cites W2065234785 @default.
• W2048440069 cites W2066876762 @default.
• W2048440069 cites W2071470270 @default.
• W2048440069 cites W2077342837 @default.
• W2048440069 cites W2077363766 @default.
• W2048440069 cites W2079057075 @default.
• W2048440069 cites W2081247969 @default.
• W2048440069 cites W2085880972 @default.
• W2048440069 cites W2095353118 @default.
• W2048440069 cites W2096662041 @default.
• W2048440069 cites W2100991702 @default.
• W2048440069 cites W2103834956 @default.
• W2048440069 cites W2110476813 @default.
• W2048440069 cites W2110715199 @default.
• W2048440069 cites W2119362790 @default.
• W2048440069 cites W2121043575 @default.
• W2048440069 cites W2121887268 @default.
• W2048440069 cites W2122947990 @default.
• W2048440069 cites W2131188959 @default.
• W2048440069 cites W2136257629 @default.
• W2048440069 cites W2139782112 @default.
• W2048440069 cites W2142217243 @default.
• W2048440069 cites W2143633028 @default.
• W2048440069 cites W2155361926 @default.
• W2048440069 cites W2155614211 @default.
• W2048440069 cites W2159453240 @default.
• W2048440069 cites W2163376196 @default.
• W2048440069 cites W2405442390 @default.
• W2048440069 cites W2460973471 @default.
• W2048440069 cites W246916078 @default.
• W2048440069 cites W41331821 @default.
• W2048440069 cites W4244801441 @default.
• W2048440069 cites W4244863872 @default.
• W2048440069 doi "https://doi.org/10.1007/s10549-007-9748-8" @default.
• W2048440069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2730887" @default.
• W2048440069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17882547" @default.
• W2048440069 hasPublicationYear "2007" @default.
• W2048440069 type Work @default.
• W2048440069 sameAs 2048440069 @default.
• W2048440069 citedByCount "46" @default.
• W2048440069 countsByYear W20484400692012 @default.
• W2048440069 countsByYear W20484400692013 @default.
• W2048440069 countsByYear W20484400692014 @default.
• W2048440069 countsByYear W20484400692015 @default.
• W2048440069 countsByYear W20484400692016 @default.
• W2048440069 countsByYear W20484400692017 @default.
• W2048440069 countsByYear W20484400692018 @default.
• W2048440069 countsByYear W20484400692019 @default.
• W2048440069 countsByYear W20484400692021 @default.
• W2048440069 countsByYear W20484400692022 @default.
• W2048440069 crossrefType "journal-article" @default.
• W2048440069 hasAuthorship W2048440069A5007017426 @default.
• W2048440069 hasAuthorship W2048440069A5027738013 @default.
• W2048440069 hasAuthorship W2048440069A5029314163 @default.
• W2048440069 hasAuthorship W2048440069A5047347828 @default.

• next