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• W2048444845 abstract "An adenylate cyclase inhibitor, RMI 12330A, is able to depress cAMP synthesis stimulated by serotonin in the abdominal ganglion of Aplysia depilans and punctata. This substance reversibly blocked the heterosynaptic facilitation, induced by activation of serotonergic pathways, of the EPSP recorded from L7 motoneuron in abdominal ganglion after electrical stimulation of the siphon nerve. RMI 12330A, injected into whole unrestrained animals, inhibited the short-term dishabituation of the siphon withdrawal reflex. These findings demonstrate that the increase of endogenous cAMP in the sensory neurons mediating the gill and siphon withdrawal reflex is an essential step in the mechanism of potentiation of the transmitter output underlying heterosynaptic facilitation and short-term behavioral sensitization." @default.
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• W2048444845 date "1983-12-01" @default.
• W2048444845 modified "2023-10-16" @default.
• W2048444845 title "Heterosynaptic facilitation and behavioral sensitization are inhibited by lowering endogenous cAMP inAplysia" @default.
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• W2048444845 doi "https://doi.org/10.1016/0006-8993(83)90084-7" @default.
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